Cheap Flight Tickets from Knoxville (TYS) to St Louis (STL), Starting at $416

Good to Know: Cheapest and Fastest TYS - STL Flights

Useful information for finding best airline tickets from McGhee Tyson to Lambert St Louis International on your next trip.

Cheapest Round Trip Flight

$416

DL Delta Airlines • 1 stop • 8h 24m

Jul 20 – Jul 27

The cheapest round trip flight from Knoxville to St Louis (TYS-STL-TYS) is currently $416

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Fastest Flight

6h 54m

The fastest nonstop flight from Knoxville to St Louis (TYS-STL) takes 6h 54m

Top Airlines Flying from Knoxville to St Louis

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

Latest Flight Deals from Knoxville (TYS) to St Louis (STL)

Compare and book low fare round-trip air tickets from Knoxville to St Louis. Ideal for travelers with confirmed return itineraries.

Jul 20 - Jul 27, Economy
DL
Knoxville → St Louis
8h 24m
7:49 PM - 11:53 PM • 1 stop
DL
Knoxville → St Louis
5h 54m
6:58 PM - 11:52 PM • 1 stop
$416
Delta Airlines
Jul 20 - Jul 27, Economy
DL
Knoxville → St Louis
6h 54m
5:23 PM - 8:37 PM • 1 stop
DL
Knoxville → St Louis
10h 16m
6:00 AM - 1:16 PM • 1 stop
$456
Delta Airlines
Jul 20 - Jul 27, Economy
WN
Knoxville → St Louis
14h 10m
2:20 PM - 10:10 PM • 1 stop
WN
Knoxville → St Louis
4h
5:35 PM - 9:15 PM • 1 stop
$527
Southwest Airlines
Jul 20 - Jul 27, Economy
WN
Knoxville → St Louis
12h 5m
4:20 PM - 10:45 PM • 1 stop
WN
Knoxville → St Louis
4h
5:35 PM - 9:15 PM • 1 stop
$527
Southwest Airlines
Jul 20 - Jul 27, Economy
WN
Knoxville → St Louis
15h 40m
6:40 AM - 3:20 PM • 2 stops
WN
Knoxville → St Louis
4h
5:35 PM - 9:15 PM • 1 stop
$537
Southwest Airlines
Jul 20 - Jul 27, Economy
WN
Knoxville → St Louis
12h 35m
12:35 PM - 7:30 PM • 2 stops
WN
Knoxville → St Louis
4h
5:35 PM - 9:15 PM • 1 stop
$537
Southwest Airlines

Fly from Knoxville to St Louis with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to St Louis? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to St Louis Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to STL?
The most popular airline flying from Knoxville to St Louis are
Can I fly from TYS to STL non-stop?
NO
Which airlines fly nonstop between Knoxville and St Louis?
The non-stop flights between Knoxville and St Louis are .
What’s the earliest departure time from TYS to STL Airport?
The earliest flight leaves TYS at 6:40 am and lands in STL - Lambert St Louis International
What are the airports in St Louis?
STL
Can I make changes to my Knoxville to St Louis flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to STL?
Read the fare rules of the Knoxville to St Louis air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and St Louis?
operate flights between Knoxville and St Louis
How long does a flight from Knoxville to St Louis take?
It takes approximately 1 hour to fly non-stop from TYS to STL, which is 405.43 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to St Louis (STL) ?
In the past couple of days, the cheapest tickets to STL from TYS were found on WN : USD 537
Do I need a passport to fly between TYS and STL?
No
What’s the latest departure time from TYS to STL ?
The last flight leaves TYS at 7:49 pm

Knoxville (TYS) to St Louis (STL): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport Lambert St Louis International , St Louis, US
Distance 405 miles

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