Cheap Flight Tickets from Knoxville (TYS) to St Louis (STL), Starting at $100

Good to Know: Cheapest and Fastest TYS - STL Flights

Useful information for finding best airline tickets from McGhee Tyson to Lambert St Louis International on your next trip.

Cheapest One way Flight

$100

WN Southwest Airlines • 2 stops • 25h 15m

Sep 22

The cheapest one way flight from Knoxville to St Louis (TYS-STL) is currently $100

🔍 Search Flights

Fastest Flight

13h 22m

The fastest nonstop flight from Knoxville to St Louis (TYS-STL) takes 13h 22m

Top Airlines Flying from Knoxville to St Louis

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Knoxville (TYS) to St Louis (STL)

Fly from Knoxville to St Louis with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to St Louis? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to St Louis Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to STL?
The most popular airline flying from Knoxville to St Louis are
Can I fly from TYS to STL non-stop?
NO
Which airlines fly nonstop between Knoxville and St Louis?
The non-stop flights between Knoxville and St Louis are .
What’s the earliest departure time from TYS to STL Airport?
The earliest flight leaves TYS at 7:00 am and lands in STL - Lambert St Louis International
What are the airports in St Louis?
STL
Can I make changes to my Knoxville to St Louis flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to STL?
Read the fare rules of the Knoxville to St Louis air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and St Louis?
operate flights between Knoxville and St Louis
How long does a flight from Knoxville to St Louis take?
It takes approximately 1 hour to fly non-stop from TYS to STL, which is 405.43 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to St Louis (STL) ?
In the past couple of days, the cheapest tickets to STL from TYS were found on DL : USD 635
Do I need a passport to fly between TYS and STL?
No
What’s the latest departure time from TYS to STL ?
The last flight leaves TYS at 4:40 pm

Knoxville (TYS) to St Louis (STL): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport Lambert St Louis International , St Louis, US
Distance 405 miles

More Flight Options for Knoxville (TYS) and St Louis (STL)

Why Fareleaders for TYS to STL Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Knoxville to St Louis flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on TYS to STL flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Knoxville to St Louis flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Knoxville (TYS) to St Louis (STL)
Terms and Conditions*