Cheap Flight Tickets from Knoxville (TYS) to Chicago (ORD), Starting at $211

Good to Know: Cheapest and Fastest TYS - ORD Flights

Useful information for finding best airline tickets from McGhee Tyson to Chicago O'Hare International on your next trip.

Cheapest Round Trip Flight

$438

DL Delta Airlines • 1 stop • 8h 51m

Oct 23 – Nov 02

The cheapest round trip flight from Knoxville to Chicago (TYS-ORD-TYS) is currently $438

🔍 Search Flights

Cheapest Direct Flight

$211

AA American Airlines • nonstop • 3h 30m

Sep 12

The cheapest nonstop flight from Knoxville to Chicago (TYS-ORD) is currently $211

🔍 Search Flights

Fastest Flight

2h 38m

The fastest nonstop flight from Knoxville to Chicago (TYS-ORD) takes 2h 38m

Top Airlines Flying from Knoxville to Chicago

Delta Airline, DL

Delta Airlines

Latest Flight Deals from Knoxville (TYS) to Chicago (ORD)

Compare and book low fare round-trip air tickets from Knoxville to Chicago. Ideal for travelers with confirmed return itineraries.

Oct 23 - Nov 02, Economy
DL
Knoxville → Chicago
8h 51m
5:40 AM - 10:11 AM • 1 stop
DL
Knoxville → Chicago
6h 59m
1:23 PM - 6:42 PM • 1 stop
$438
Delta Airlines
Oct 23 - Nov 02, Economy
DL
Knoxville → Chicago
9h 7m
11:45 AM - 4:32 PM • 1 stop
DL
Knoxville → Chicago
7h 6m
8:05 AM - 1:31 PM • 1 stop
$438
Delta Airlines
Oct 23 - Nov 02, Economy
DL
Knoxville → Chicago
6h 42m
7:09 AM - 10:11 AM • 1 stop
DL
Knoxville → Chicago
5h 51m
10:35 AM - 3:26 PM • 1 stop
$438
Delta Airlines
Oct 23 - Nov 02, Economy
DL
Knoxville → Chicago
7h 39m
10:29 AM - 2:28 PM • 1 stop
DL
Knoxville → Chicago
10h 3m
10:35 AM - 5:38 PM • 1 stop
$438
Delta Airlines
Oct 23 - Nov 02, Economy
DL
Knoxville → Chicago
5h 59m
5:40 AM - 8:39 AM • 1 stop
DL
Knoxville → Chicago
5h 51m
10:35 AM - 3:26 PM • 1 stop
$438
Delta Airlines
Oct 23 - Nov 02, Economy
DL
Knoxville → Chicago
8h 53m
2:38 PM - 7:11 PM • 1 stop
DL
Knoxville → Chicago
9h 5m
1:23 PM - 8:08 PM • 1 stop
$438
Delta Airlines

Fly from Knoxville to Chicago with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to Chicago? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to Chicago Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to ORD?
The most popular airline flying from Knoxville to Chicago are
Can I fly from TYS to ORD non-stop?
Yes, you can fly TYS to ORD non-stop on
Which airlines fly nonstop between Knoxville and Chicago?
The non-stop flights between Knoxville and Chicago are .
What’s the earliest departure time from TYS to ORD Airport?
The earliest flight leaves TYS at 5:40 am and lands in ORD - Chicago O'Hare International
What are the airports in Chicago?
MDW,ORD
Can I make changes to my Knoxville to Chicago flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to ORD?
Read the fare rules of the Knoxville to Chicago air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and Chicago?
operate flights between Knoxville and Chicago
How long does a flight from Knoxville to Chicago take?
It takes approximately 2 hour to fly non-stop from TYS to ORD, which is 474.67 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to Chicago (ORD) ?
In the past couple of days, the cheapest tickets to ORD from TYS were found on DL : USD 438
Do I need a passport to fly between TYS and ORD?
No
What’s the latest departure time from TYS to ORD ?
The last flight leaves TYS at 8:15 pm

Knoxville (TYS) to Chicago (ORD): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport Chicago O'Hare International , Chicago, US
Distance 475 miles

More Flight Options for Knoxville (TYS) and Chicago (ORD)

Why Fareleaders for TYS to ORD Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Knoxville to Chicago flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on TYS to ORD flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Knoxville to Chicago flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Knoxville (TYS) to Chicago (ORD)
Terms and Conditions*