Cheap Flight Tickets from Knoxville (TYS) to Santa Ana (SNA), Starting at $338

Good to Know: Cheapest and Fastest TYS - SNA Flights

Useful information for finding best airline tickets from McGhee Tyson to John Wayne -Orange County on your next trip.

Cheapest Round Trip Flight

$338

WN Southwest Airlines • 1 stop • 12h 5m

Nov 09 – Nov 11

The cheapest round trip flight from Knoxville to Santa Ana (TYS-SNA-TYS) is currently $338

🔍 Search Flights

Fastest Flight

11h 53m

The fastest nonstop flight from Knoxville to Santa Ana (TYS-SNA) takes 11h 53m

Top Airlines Flying from Knoxville to Santa Ana

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Knoxville (TYS) to Santa Ana (SNA)

Compare and book low fare round-trip air tickets from Knoxville to Santa Ana. Ideal for travelers with confirmed return itineraries.

Nov 09 - Nov 11, Economy
WN
Knoxville → Santa Ana
12h 5m
5:25 PM - 9:50 PM • 1 stop
WN
Knoxville → Santa Ana
13h 35m
8:35 AM - 7:50 PM • 2 stops
$338
Southwest Airlines
Nov 09 - Nov 11, Economy
WN
Knoxville → Santa Ana
19h 5m
8:10 AM - 4:55 PM • 2 stops
WN
Knoxville → Santa Ana
13h 35m
8:35 AM - 7:50 PM • 2 stops
$671
Southwest Airlines
Nov 09 - Nov 11, Economy
WN
Knoxville → Santa Ana
18h 55m
8:10 AM - 4:45 PM • 2 stops
WN
Knoxville → Santa Ana
13h 35m
8:35 AM - 7:50 PM • 2 stops
$671
Southwest Airlines
Nov 09 - Nov 11, Economy
AA
Knoxville → Santa Ana
11h 53m
6:50 AM - 11:03 AM • 1 stop
AA
Knoxville → Santa Ana
10h 48m
9:12 AM - 7:00 PM • 1 stop
$679
American Airlines
Nov 09 - Nov 11, Economy
UA
Knoxville → Santa Ana
12h 28m
5:40 PM - 10:28 PM • 1 stop
UA
Knoxville → Santa Ana
10h 23m
1:09 PM - 10:32 PM • 1 stop
$679
United Airlines
Nov 09 - Nov 11, Economy
WN
Knoxville → Santa Ana
15h 10m
3:40 PM - 9:50 PM • 2 stops
WN
Knoxville → Santa Ana
13h 35m
8:35 AM - 7:50 PM • 2 stops
$691
Southwest Airlines

Fly from Knoxville to Santa Ana with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to Santa Ana? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to Santa Ana Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to SNA?
The most popular airline flying from Knoxville to Santa Ana are
Can I fly from TYS to SNA non-stop?
NO
Which airlines fly nonstop between Knoxville and Santa Ana?
The non-stop flights between Knoxville and Santa Ana are .
What’s the earliest departure time from TYS to SNA Airport?
The earliest flight leaves TYS at 6:50 am and lands in SNA - John Wayne -Orange County
What are the airports in Santa Ana?
SNA
Can I make changes to my Knoxville to Santa Ana flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to SNA?
Read the fare rules of the Knoxville to Santa Ana air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and Santa Ana?
operate flights between Knoxville and Santa Ana
How long does a flight from Knoxville to Santa Ana take?
It takes approximately 4 hour to fly non-stop from TYS to SNA, which is 1923.48 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to Santa Ana (SNA) ?
In the past couple of days, the cheapest tickets to SNA from TYS were found on WN : USD 671
Do I need a passport to fly between TYS and SNA?
No
What’s the latest departure time from TYS to SNA ?
The last flight leaves TYS at 5:40 pm

Knoxville (TYS) to Santa Ana (SNA): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport John Wayne -Orange County , Santa Ana, US
Distance 1923 miles

More Flight Options for Knoxville (TYS) and Santa Ana (SNA)

Why Fareleaders for TYS to SNA Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Knoxville to Santa Ana flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on TYS to SNA flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Knoxville to Santa Ana flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Knoxville (TYS) to Santa Ana (SNA)
Terms and Conditions*