Cheap Flight Tickets from Knoxville (TYS) to Chicago (MDW), Starting at $159

Good to Know: Cheapest and Fastest TYS - MDW Flights

Useful information for finding best airline tickets from McGhee Tyson to Chicago Midway International on your next trip.

Cheapest Round Trip Flight

$159

DL Delta Airlines • 1 stop • 10h 36m

Sep 05 – Sep 09

The cheapest round trip flight from Knoxville to Chicago (TYS-MDW-TYS) is currently $159

🔍 Search Flights

Cheapest One way Flight

$233

WN Southwest Airlines • 2 stops • 42h

Sep 19

The cheapest one way flight from Knoxville to Chicago (TYS-MDW) is currently $233

🔍 Search Flights

Cheapest Direct Flight

$437

UA United Airlines • nonstop • 2h 35m

Sep 14

The cheapest nonstop flight from Knoxville to Chicago (TYS-MDW) is currently $437

🔍 Search Flights

Fastest Flight

2h 35m

The fastest nonstop flight from Knoxville to Chicago (TYS-MDW) takes 2h 35m

Top Airlines Flying from Knoxville to Chicago

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

Latest Flight Deals from Knoxville (TYS) to Chicago (MDW)

Compare and book low fare round-trip air tickets from Knoxville to Chicago. Ideal for travelers with confirmed return itineraries.

Sep 05 - Sep 09, Economy
DL
Knoxville → Chicago
10h 36m
5:00 PM - 10:36 PM • 1 stop
DL
Knoxville → Chicago
8h 55m
8:05 AM - 2:40 PM • 1 stop
$159
Delta Airlines
Sep 05 - Sep 09, Economy
DL
Knoxville → Chicago
10h 21m
11:38 AM - 4:59 PM • 1 stop
DL
Knoxville → Chicago
5h 39m
6:05 AM - 10:44 AM • 1 stop
$287
Delta Airlines
Sep 05 - Sep 09, Economy
DL
Knoxville → Chicago
10h 16m
10:28 AM - 3:44 PM • 1 stop
DL
Knoxville → Chicago
5h 39m
6:05 AM - 10:44 AM • 1 stop
$287
Delta Airlines
Sep 05 - Sep 09, Economy
WN
Knoxville → Chicago
9h
12:30 PM - 5:10 PM • 1 stop
WN
Knoxville → Chicago
9h 10m
6:15 AM - 1:05 PM • 1 stop
$368
Southwest Airlines
Sep 05 - Sep 09, Economy
WN
Knoxville → Chicago
9h
12:30 PM - 5:10 PM • 1 stop
WN
Knoxville → Chicago
10h 20m
12:35 PM - 7:55 PM • 2 stops
$374
Southwest Airlines
Sep 05 - Sep 09, Economy
WN
Knoxville → Chicago
5h 25m
4:55 PM - 7:20 PM • 1 stop
WN
Knoxville → Chicago
8h 20m
1:00 PM - 7:00 PM • 2 stops
$374
Southwest Airlines

Fly from Knoxville to Chicago with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to Chicago? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to Chicago Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to MDW?
The most popular airline flying from Knoxville to Chicago are
Can I fly from TYS to MDW non-stop?
Yes, you can fly TYS to MDW non-stop on
Which airlines fly nonstop between Knoxville and Chicago?
The non-stop flights between Knoxville and Chicago are .
What’s the earliest departure time from TYS to MDW Airport?
The earliest flight leaves TYS at 6:00 am and lands in MDW - Chicago Midway International
What are the airports in Chicago?
ORD,MDW
Can I make changes to my Knoxville to Chicago flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to MDW?
Read the fare rules of the Knoxville to Chicago air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and Chicago?
operate flights between Knoxville and Chicago
How long does a flight from Knoxville to Chicago take?
It takes approximately 2 hour to fly non-stop from TYS to MDW, which is 459.25 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to Chicago (MDW) ?
In the past couple of days, the cheapest tickets to MDW from TYS were found on AA : USD 386
Do I need a passport to fly between TYS and MDW?
No
What’s the latest departure time from TYS to MDW ?
The last flight leaves TYS at 5:00 pm

Knoxville (TYS) to Chicago (MDW): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport Chicago Midway International , Chicago, US
Distance 459 miles

More Flight Options for Knoxville (TYS) and Chicago (MDW)

Why Fareleaders for TYS to MDW Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Knoxville to Chicago flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on TYS to MDW flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Knoxville to Chicago flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Knoxville (TYS) to Chicago (MDW)
Terms and Conditions*