Cheap Flight Tickets from Knoxville (TYS) to Chicago (MDW), Starting at $181

Good to Know: Cheapest and Fastest TYS - MDW Flights

Useful information for finding best airline tickets from McGhee Tyson to Chicago Midway International on your next trip.

Cheapest Round Trip Flight

$181

WN Southwest Airlines • 1 stop • 7h 30m

Sep 16 – Sep 23

The cheapest round trip flight from Knoxville to Chicago (TYS-MDW-TYS) is currently $181

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Fastest Flight

7h 30m

The fastest nonstop flight from Knoxville to Chicago (TYS-MDW) takes 7h 30m

Top Airlines Flying from Knoxville to Chicago

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

Latest Flight Deals from Knoxville (TYS) to Chicago (MDW)

Compare and book low fare round-trip air tickets from Knoxville to Chicago. Ideal for travelers with confirmed return itineraries.

Sep 16 - Sep 23, Economy
WN
Knoxville → Chicago
7h 30m
7:00 AM - 10:50 AM • 1 stop
WN
Knoxville → Chicago
17h
7:40 AM - 7:00 PM • 1 stop
$181
Southwest Airlines
Sep 16 - Sep 23, Economy
DL
Knoxville → Chicago
12h 28m
11:45 AM - 6:33 PM • 1 stop
DL
Knoxville → Chicago
6h 53m
6:05 AM - 11:18 AM • 1 stop
$252
Delta Airlines
Sep 16 - Sep 23, Economy
DL
Knoxville → Chicago
19h 3m
7:50 AM - 6:33 PM • 2 stops
DL
Knoxville → Chicago
6h 53m
6:05 AM - 11:18 AM • 1 stop
$281
Delta Airlines
Sep 16 - Sep 23, Economy
DL
Knoxville → Chicago
13h 40m
8:55 AM - 4:15 PM • 1 stop
DL
Knoxville → Chicago
6h 53m
6:05 AM - 11:18 AM • 1 stop
$297
Delta Airlines
Sep 16 - Sep 23, Economy
DL
Knoxville → Chicago
8h 51m
6:13 PM - 10:44 PM • 1 stop
DL
Knoxville → Chicago
15h 46m
9:29 AM - 8:15 PM • 2 stops
$326
Delta Airlines
Sep 16 - Sep 23, Economy
DL
Knoxville → Chicago
10h 49m
10:26 AM - 4:15 PM • 1 stop
DL
Knoxville → Chicago
15h 46m
9:29 AM - 8:15 PM • 2 stops
$326
Delta Airlines

Fly from Knoxville to Chicago with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to Chicago? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to Chicago Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to MDW?
The most popular airline flying from Knoxville to Chicago are
Can I fly from TYS to MDW non-stop?
NO
Which airlines fly nonstop between Knoxville and Chicago?
The non-stop flights between Knoxville and Chicago are .
What’s the earliest departure time from TYS to MDW Airport?
The earliest flight leaves TYS at 7:00 am and lands in MDW - Chicago Midway International
What are the airports in Chicago?
ORD,MDW
Can I make changes to my Knoxville to Chicago flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to MDW?
Read the fare rules of the Knoxville to Chicago air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and Chicago?
operate flights between Knoxville and Chicago
How long does a flight from Knoxville to Chicago take?
It takes approximately 2 hour to fly non-stop from TYS to MDW, which is 459.25 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to Chicago (MDW) ?
In the past couple of days, the cheapest tickets to MDW from TYS were found on DL : USD 297
Do I need a passport to fly between TYS and MDW?
No
What’s the latest departure time from TYS to MDW ?
The last flight leaves TYS at 6:13 pm

Knoxville (TYS) to Chicago (MDW): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport Chicago Midway International , Chicago, US
Distance 459 miles

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