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Uncover the best deals on St Louis to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest STL - TYS Flights
Useful information for finding best airline tickets from Lambert St Louis International to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$306
Southwest Airlines
• 1 stop
• 12h 5m
Oct 15 – Oct 19
The cheapest round trip flight from St Louis to Knoxville (STL-TYS-STL) is currently $306
Fastest Flight
5h 33m
The fastest nonstop flight from St Louis to Knoxville (STL-TYS) takes 5h 33m
Latest Flight Deals from St Louis (STL) to Knoxville (TYS)
Compare and book low fare round-trip air tickets from St Louis to Knoxville. Ideal for travelers with confirmed return itineraries.
Oct 15 - Oct 19, Economy
St Louis → Knoxville
12h 5m
8:30 AM - 4:55 PM • 1 stop
St Louis → Knoxville
8h 35m
7:25 PM - 11:40 PM • 1 stop
Southwest Airlines
Oct 15 - Oct 19, Economy
St Louis → Knoxville
11h 55m
2:30 PM - 10:45 PM • 1 stop
St Louis → Knoxville
8h 35m
7:25 PM - 11:40 PM • 1 stop
Southwest Airlines
Oct 15 - Oct 19, Economy
St Louis → Knoxville
5h 55m
5:50 PM - 10:45 PM • 1 stop
St Louis → Knoxville
15h 10m
12:50 PM - 9:00 PM • 2 stops
Southwest Airlines
Oct 15 - Oct 19, Economy
St Louis → Knoxville
5h 33m
5:35 PM - 10:08 PM • 1 stop
St Louis → Knoxville
7h 9m
5:40 AM - 9:09 AM • 1 stop
Delta Airlines
Oct 15 - Oct 19, Economy
St Louis → Knoxville
15h 15m
8:35 AM - 6:50 PM • 1 stop
St Louis → Knoxville
8h 35m
7:25 PM - 11:40 PM • 1 stop
Southwest Airlines
FAQs on St Louis to Knoxville Flights
What are the airports in St Louis?
STL
What’s the most popular airline flying from STL to TYS?
The most popular airline flying from St Louis to Knoxville are
Can I fly from STL to TYS non-stop?
NO
Which airlines fly nonstop between St Louis and Knoxville?
The non-stop flights between St Louis and Knoxville are .
What’s the earliest departure time from STL to TYS Airport?
The earliest flight leaves STL at 5:00 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my St Louis to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from STL to TYS?
Read the fare rules of the St Louis to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from St Louis and Knoxville?
operate flights between St Louis and Knoxville
How long does a flight from St Louis to Knoxville take?
It takes approximately 1 hour to fly non-stop from STL to TYS, which is 405.43 miles by air.
Which airlines provide the cheapest flights from St Louis (STL) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from STL were found on WN : USD 306
Do I need a passport to fly between STL and TYS?
No
What’s the latest departure time from STL to TYS ?
The last flight leaves STL at 5:50 pm
St Louis (STL) to Knoxville (TYS): Airport Information
| Origin Airport | Lambert St Louis International , St Louis, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 405 miles |
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