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Uncover the best deals on Detroit to St Louis flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest DTW - STL Flights
Useful information for finding best airline tickets from Detroit Metropolitan Wayne County to Lambert St Louis International on your next trip.
Cheapest Round Trip Flight
$169
Frontier Airlines
• 1 stop
• 20h 15m
Nov 13 – Nov 14
The cheapest round trip flight from Detroit to St Louis (DTW-STL-DTW) is currently $169
Cheapest One way Flight
$65
Southwest Airlines
• nonstop
• 2h 30m
Sep 17
The cheapest one way flight from Detroit to St Louis (DTW-STL) is currently $65
Cheapest Direct Flight
$193
Southwest Airlines
• nonstop
• 2h 25m
Nov 13
The cheapest nonstop flight from Detroit to St Louis (DTW-STL) is currently $193
Fastest Flight
2h 17m
The fastest nonstop flight from Detroit to St Louis (DTW-STL) takes 2h 17m
Top Airlines Flying from Detroit to St Louis
Latest Flight Deals from Detroit (DTW) to St Louis (STL)
Compare and book low fare round-trip air tickets from Detroit to St Louis. Ideal for travelers with confirmed return itineraries.
Nov 13 - Nov 14, Economy
Detroit → St Louis
20h 15m
6:25 AM - 5:40 PM • 1 stop
Detroit → St Louis
25h 26m
4:26 PM - 8:52 AM • 1 stop
Frontier Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
7h 4m
7:58 PM - 11:22 PM • 1 stop
Detroit → St Louis
2h 13m
6:40 AM - 9:13 AM • nonstop
Delta Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
8h 20m
8:20 AM - 12:20 PM • 1 stop
Detroit → St Louis
2h 15m
2:55 PM - 5:30 PM • nonstop
Southwest Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
10h 6m
7:15 AM - 12:21 PM • 1 stop
Detroit → St Louis
2h 16m
4:39 PM - 7:15 PM • nonstop
Delta Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
6h 50m
8:45 PM - 11:55 PM • 1 stop
Detroit → St Louis
9h 5m
8:55 AM - 3:40 PM • 1 stop
Southwest Airlines
Explore competitive one-way airfare options for DTW - STL flights. Best suited for flexible or open-ended travel plans.
Looking for the fastest way to St Louis? These direct flight options from DTW to STL offer both convenience and value—no layovers, just straight to your destination.
Nov 13 - Nov 14, Economy
Detroit → St Louis
2h 25m
8:15 PM - 9:00 PM • nonstop
Detroit → St Louis
2h 15m
2:55 PM - 5:30 PM • nonstop
Southwest Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
2h 24m
7:45 PM - 8:29 PM • nonstop
Detroit → St Louis
2h 13m
6:40 AM - 9:13 AM • nonstop
Delta Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
2h 35m
6:50 AM - 7:45 AM • nonstop
Detroit → St Louis
2h 15m
2:55 PM - 5:30 PM • nonstop
Southwest Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
2h 25m
8:40 AM - 9:25 AM • nonstop
Detroit → St Louis
2h 12m
10:20 AM - 12:52 PM • nonstop
Delta Airlines
Nov 13 - Nov 14, Economy
Detroit → St Louis
2h 23m
12:40 PM - 1:23 PM • nonstop
Detroit → St Louis
2h 13m
6:40 AM - 9:13 AM • nonstop
Delta Airlines
FAQs on Detroit to St Louis Flights
What are the airports in Detroit?
DTW
What’s the most popular airline flying from DTW to STL?
The most popular airline flying from Detroit to St Louis are
Can I fly from DTW to STL non-stop?
Yes, you can fly DTW to STL non-stop on
Which airlines fly nonstop between Detroit and St Louis?
The non-stop flights between Detroit and St Louis are .
What’s the earliest departure time from DTW to STL Airport?
The earliest flight leaves DTW at 6:25 am and lands in STL - Lambert St Louis International
What are the airports in St Louis?
STL
Can I make changes to my Detroit to St Louis flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from DTW to STL?
Read the fare rules of the Detroit to St Louis air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Detroit and St Louis?
operate flights between Detroit and St Louis
How long does a flight from Detroit to St Louis take?
It takes approximately 1 hour to fly non-stop from DTW to STL, which is 439.98 miles by air.
Which airlines provide the cheapest flights from Detroit (DTW) to St Louis (STL) ?
In the past couple of days, the cheapest tickets to STL from DTW were found on UA : USD 156
Do I need a passport to fly between DTW and STL?
No
What’s the latest departure time from DTW to STL ?
The last flight leaves DTW at 8:45 pm
Detroit (DTW) to St Louis (STL): Airport Information
| Origin Airport | Detroit Metropolitan Wayne County , Detroit, US |
| Destination Airport | Lambert St Louis International , St Louis, US |
| Distance | 440 miles |
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