Cheap Flight Tickets from San Francisco (SFO) to Knoxville (TYS), Starting at $596

Good to Know: Cheapest and Fastest SFO - TYS Flights

Useful information for finding best airline tickets from San Francisco International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$596

DL Delta Airlines • 1 stop • 15h 9m

Oct 20 – Oct 27

The cheapest round trip flight from San Francisco to Knoxville (SFO-TYS-SFO) is currently $596

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Fastest Flight

10h 57m

The fastest nonstop flight from San Francisco to Knoxville (SFO-TYS) takes 10h 57m

Top Airlines Flying from San Francisco to Knoxville

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Alaska Airlines -AS

Alaska Airlines

Latest Flight Deals from San Francisco (SFO) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from San Francisco to Knoxville. Ideal for travelers with confirmed return itineraries.

Oct 20 - Oct 27, Economy
DL
San Francisco → Knoxville
15h 9m
9:25 PM - 9:34 AM • 1 stop
DL
San Francisco → Knoxville
15h 32m
11:45 AM - 6:17 PM • 1 stop
$596
Delta Airlines
Oct 20 - Oct 27, Economy
DL
San Francisco → Knoxville
15h 29m
10:25 PM - 10:54 AM • 1 stop
DL
San Francisco → Knoxville
15h 32m
11:45 AM - 6:17 PM • 1 stop
$596
Delta Airlines
Oct 20 - Oct 27, Economy
WN
San Francisco → Knoxville
15h 40m
11:40 PM - 12:20 PM • 2 stops
WN
San Francisco → Knoxville
17h 10m
3:20 PM - 10:50 PM • 2 stops
$607
Southwest Airlines
Oct 20 - Oct 27, Economy
WN
San Francisco → Knoxville
27h 30m
6:50 PM - 2:40 PM • 2 stops
WN
San Francisco → Knoxville
13h 55m
5:15 PM - 10:50 PM • 2 stops
$607
Southwest Airlines
Oct 20 - Oct 27, Economy
WN
San Francisco → Knoxville
15h 40m
11:40 PM - 12:20 PM • 2 stops
WN
San Francisco → Knoxville
19h 10m
7:15 AM - 4:05 PM • 3 stops
$612
Southwest Airlines
Oct 20 - Oct 27, Economy
DL
San Francisco → Knoxville
10h 57m
11:40 AM - 9:37 PM • 1 stop
DL
San Francisco → Knoxville
15h 32m
11:45 AM - 6:17 PM • 1 stop
$637
Delta Airlines

Fly from San Francisco to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from San Francisco to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on San Francisco to Knoxville Flights

What are the airports in San Francisco?
SFO
What’s the most popular airline flying from SFO to TYS?
The most popular airline flying from San Francisco to Knoxville are
Can I fly from SFO to TYS non-stop?
NO
Which airlines fly nonstop between San Francisco and Knoxville?
The non-stop flights between San Francisco and Knoxville are .
What’s the earliest departure time from SFO to TYS Airport?
The earliest flight leaves SFO at 11:40 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my San Francisco to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from SFO to TYS?
Read the fare rules of the San Francisco to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from San Francisco and Knoxville?
operate flights between San Francisco and Knoxville
How long does a flight from San Francisco to Knoxville take?
It takes approximately 5 hour to fly non-stop from SFO to TYS, which is 2119.52 miles by air.
Which airlines provide the cheapest flights from San Francisco (SFO) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from SFO were found on WN : USD 612
Do I need a passport to fly between SFO and TYS?
No
What’s the latest departure time from SFO to TYS ?
The last flight leaves SFO at 11:40 pm

San Francisco (SFO) to Knoxville (TYS): Airport Information

Origin Airport San Francisco International , San Francisco, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 2120 miles

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