Cheap Flight Tickets from Knoxville (TYS) to San Francisco (SFO), Starting at $292

Good to Know: Cheapest and Fastest TYS - SFO Flights

Useful information for finding best airline tickets from McGhee Tyson to San Francisco International on your next trip.

Cheapest Round Trip Flight

$292

DL Delta Airlines • 1 stop • 12h 12m

Oct 04 – Oct 08

The cheapest round trip flight from Knoxville to San Francisco (TYS-SFO-TYS) is currently $292

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Fastest Flight

11h 45m

The fastest nonstop flight from Knoxville to San Francisco (TYS-SFO) takes 11h 45m

Top Airlines Flying from Knoxville to San Francisco

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Knoxville (TYS) to San Francisco (SFO)

Compare and book low fare round-trip air tickets from Knoxville to San Francisco. Ideal for travelers with confirmed return itineraries.

Oct 04 - Oct 08, Economy
DL
Knoxville → San Francisco
12h 12m
7:25 PM - 11:57 PM • 1 stop
DL
Knoxville → San Francisco
12h 2m
6:05 AM - 4:27 PM • 1 stop
$292
Delta Airlines
Oct 04 - Oct 08, Economy
DL
Knoxville → San Francisco
12h 21m
5:40 AM - 10:21 AM • 1 stop
DL
Knoxville → San Francisco
10h 57m
11:40 AM - 9:37 PM • 1 stop
$292
Delta Airlines
Oct 04 - Oct 08, Economy
UA
Knoxville → San Francisco
12h 9m
3:45 PM - 8:14 PM • 1 stop
UA
Knoxville → San Francisco
10h 39m
12:35 PM - 10:14 PM • 1 stop
$373
United Airlines
Oct 04 - Oct 08, Economy
UA
Knoxville → San Francisco
12h 22m
10:42 AM - 3:24 PM • 1 stop
UA
Knoxville → San Francisco
10h 39m
12:35 PM - 10:14 PM • 1 stop
$373
United Airlines
Oct 04 - Oct 08, Economy
UA
Knoxville → San Francisco
11h 45m
9:00 AM - 1:05 PM • 1 stop
UA
Knoxville → San Francisco
12h 19m
10:10 AM - 8:49 PM • 1 stop
$373
United Airlines
Oct 04 - Oct 08, Economy
UA
Knoxville → San Francisco
13h 20m
12:05 PM - 5:05 PM • 1 stop
UA
Knoxville → San Francisco
10h 34m
6:15 AM - 3:49 PM • 1 stop
$373
United Airlines

Fly from Knoxville to San Francisco with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to San Francisco? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to San Francisco Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to SFO?
The most popular airline flying from Knoxville to San Francisco are
Can I fly from TYS to SFO non-stop?
NO
Which airlines fly nonstop between Knoxville and San Francisco?
The non-stop flights between Knoxville and San Francisco are .
What’s the earliest departure time from TYS to SFO Airport?
The earliest flight leaves TYS at 5:40 am and lands in SFO - San Francisco International
What are the airports in San Francisco?
SFO
Can I make changes to my Knoxville to San Francisco flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to SFO?
Read the fare rules of the Knoxville to San Francisco air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and San Francisco?
operate flights between Knoxville and San Francisco
How long does a flight from Knoxville to San Francisco take?
It takes approximately 5 hour to fly non-stop from TYS to SFO, which is 2119.52 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to San Francisco (SFO) ?
In the past couple of days, the cheapest tickets to SFO from TYS were found on UA : USD 373
Do I need a passport to fly between TYS and SFO?
No
What’s the latest departure time from TYS to SFO ?
The last flight leaves TYS at 7:25 pm

Knoxville (TYS) to San Francisco (SFO): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport San Francisco International , San Francisco, US
Distance 2120 miles

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