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Uncover the best deals on New Orleans to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest MSY - TYS Flights
Useful information for finding best airline tickets from Louis Armstrong New Orleans International to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$388
Southwest Airlines
• 2 stops
• 23h 50m
Nov 20 – Nov 24
The cheapest round trip flight from New Orleans to Knoxville (MSY-TYS-MSY) is currently $388
Fastest Flight
5h 20m
The fastest nonstop flight from New Orleans to Knoxville (MSY-TYS) takes 5h 20m
Top Airlines Flying from New Orleans to Knoxville
Latest Flight Deals from New Orleans (MSY) to Knoxville (TYS)
Compare and book low fare round-trip air tickets from New Orleans to Knoxville. Ideal for travelers with confirmed return itineraries.
Nov 20 - Nov 24, Economy
New Orleans → Knoxville
23h 50m
9:45 PM - 1:15 PM • 2 stops
New Orleans → Knoxville
12h 10m
12:40 PM - 7:10 PM • 1 stop
Southwest Airlines
Nov 20 - Nov 24, Economy
New Orleans → Knoxville
24h 5m
9:30 PM - 1:15 PM • 2 stops
New Orleans → Knoxville
25h 35m
7:05 AM - 9:40 PM • 3 stops
Southwest Airlines
Nov 20 - Nov 24, Economy
New Orleans → Knoxville
15h 40m
11:00 AM - 9:40 PM • 1 stop
New Orleans → Knoxville
9h 5m
12:40 PM - 5:25 PM • 1 stop
Southwest Airlines
Nov 20 - Nov 24, Economy
New Orleans → Knoxville
20h
7:30 AM - 8:30 PM • 2 stops
New Orleans → Knoxville
12h 10m
12:40 PM - 7:10 PM • 1 stop
Southwest Airlines
Nov 20 - Nov 24, Economy
New Orleans → Knoxville
20h 20m
7:10 AM - 8:30 PM • 2 stops
New Orleans → Knoxville
12h 10m
12:40 PM - 7:10 PM • 1 stop
Southwest Airlines
Flying to Knoxville soon? We've surfaced some of the most affordable last-minute flights from New Orleans to Knoxville, ideal for urgent plans or spontaneous trips.
Jul 15 - Jul 22, Economy
New Orleans → Knoxville
9h 10m
5:02 PM - 11:52 PM • 1 stop
New Orleans → Knoxville
5h 24m
5:40 AM - 8:04 AM • 1 stop
Delta Airlines
Jul 15 - Jul 22, Economy
New Orleans → Knoxville
20h
5:20 AM - 6:20 PM • 1 stop
New Orleans → Knoxville
8h 45m
6:55 PM - 11:20 PM • 1 stop
Southwest Airlines
Jul 15 - Jul 22, Economy
New Orleans → Knoxville
5h 20m
7:45 AM - 12:05 PM • 1 stop
New Orleans → Knoxville
17h 5m
7:10 AM - 4:35 PM • 2 stops
Southwest Airlines
Jul 15 - Jul 22, Economy
New Orleans → Knoxville
14h
10:45 AM - 8:25 PM • 2 stops
New Orleans → Knoxville
8h 45m
6:55 PM - 11:20 PM • 1 stop
Southwest Airlines
Jul 15 - Jul 22, Economy
New Orleans → Knoxville
10h 35m
12:50 PM - 8:25 PM • 2 stops
New Orleans → Knoxville
8h 45m
6:55 PM - 11:20 PM • 1 stop
Southwest Airlines
FAQs on New Orleans to Knoxville Flights
What are the airports in New Orleans?
MSY
What’s the most popular airline flying from MSY to TYS?
The most popular airline flying from New Orleans to Knoxville are
Can I fly from MSY to TYS non-stop?
NO
Which airlines fly nonstop between New Orleans and Knoxville?
The non-stop flights between New Orleans and Knoxville are .
What’s the earliest departure time from MSY to TYS Airport?
The earliest flight leaves MSY at 5:20 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my New Orleans to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from MSY to TYS?
Read the fare rules of the New Orleans to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from New Orleans and Knoxville?
operate flights between New Orleans and Knoxville
How long does a flight from New Orleans to Knoxville take?
It takes approximately 2 hour to fly non-stop from MSY to TYS, which is 541.32 miles by air.
Which airlines provide the cheapest flights from New Orleans (MSY) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from MSY were found on WN : USD 458
Do I need a passport to fly between MSY and TYS?
No
What’s the latest departure time from MSY to TYS ?
The last flight leaves MSY at 9:45 pm
New Orleans (MSY) to Knoxville (TYS): Airport Information
| Origin Airport | Louis Armstrong New Orleans International , New Orleans, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 541 miles |
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