Cheap Flight Tickets from New Orleans (MSY) to Knoxville (TYS), Starting at $267

Good to Know: Cheapest and Fastest MSY - TYS Flights

Useful information for finding best airline tickets from Louis Armstrong New Orleans International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$342

DL Delta Airlines • 1 stop • 5h 47m

Nov 13 – Nov 16

The cheapest round trip flight from New Orleans to Knoxville (MSY-TYS-MSY) is currently $342

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Fastest Flight

5h 13m

The fastest nonstop flight from New Orleans to Knoxville (MSY-TYS) takes 5h 13m

Top Airlines Flying from New Orleans to Knoxville

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Alaska Airlines -AS

Alaska Airlines

Latest Flight Deals from New Orleans (MSY) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from New Orleans to Knoxville. Ideal for travelers with confirmed return itineraries.

Nov 13 - Nov 16, Economy
DL
New Orleans → Knoxville
5h 47m
9:08 AM - 1:55 PM • 1 stop
DL
New Orleans → Knoxville
5h 25m
4:00 PM - 6:25 PM • 1 stop
$342
Delta Airlines
Nov 13 - Nov 16, Economy
DL
New Orleans → Knoxville
5h 13m
1:09 PM - 5:22 PM • 1 stop
DL
New Orleans → Knoxville
5h 25m
4:00 PM - 6:25 PM • 1 stop
$342
Delta Airlines
Nov 13 - Nov 16, Economy
DL
New Orleans → Knoxville
7h 38m
5:30 AM - 11:28 AM • 1 stop
DL
New Orleans → Knoxville
5h 27m
2:40 PM - 5:07 PM • 1 stop
$342
Delta Airlines
Nov 13 - Nov 16, Economy
DL
New Orleans → Knoxville
5h 58m
6:30 AM - 11:28 AM • 1 stop
DL
New Orleans → Knoxville
6h 45m
7:22 PM - 10:27 PM • 1 stop
$342
Delta Airlines
Nov 13 - Nov 16, Economy
WN
New Orleans → Knoxville
13h 40m
7:30 AM - 4:50 PM • 1 stop
WN
New Orleans → Knoxville
12h 30m
8:30 AM - 3:20 PM • 1 stop
$511
Southwest Airlines
Nov 13 - Nov 16, Economy
WN
New Orleans → Knoxville
15h 45m
11:00 AM - 9:45 PM • 1 stop
WN
New Orleans → Knoxville
10h
2:40 PM - 7:40 PM • 1 stop
$528
Southwest Airlines

Fly from New Orleans to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from New Orleans to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on New Orleans to Knoxville Flights

What are the airports in New Orleans?
MSY
What’s the most popular airline flying from MSY to TYS?
The most popular airline flying from New Orleans to Knoxville are
Can I fly from MSY to TYS non-stop?
NO
Which airlines fly nonstop between New Orleans and Knoxville?
The non-stop flights between New Orleans and Knoxville are .
What’s the earliest departure time from MSY to TYS Airport?
The earliest flight leaves MSY at 5:20 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my New Orleans to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from MSY to TYS?
Read the fare rules of the New Orleans to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from New Orleans and Knoxville?
operate flights between New Orleans and Knoxville
How long does a flight from New Orleans to Knoxville take?
It takes approximately 2 hour to fly non-stop from MSY to TYS, which is 541.32 miles by air.
Which airlines provide the cheapest flights from New Orleans (MSY) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from MSY were found on WN : USD 511
Do I need a passport to fly between MSY and TYS?
No
What’s the latest departure time from MSY to TYS ?
The last flight leaves MSY at 7:22 pm

New Orleans (MSY) to Knoxville (TYS): Airport Information

Origin Airport Louis Armstrong New Orleans International , New Orleans, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 541 miles

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