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Uncover the best deals on Detroit to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest DTW - TYS Flights
Useful information for finding best airline tickets from Detroit Metropolitan Wayne County to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$271
Southwest Airlines
• 1 stop
• 7h 35m
Oct 25 – Oct 30
The cheapest round trip flight from Detroit to Knoxville (DTW-TYS-DTW) is currently $271
Cheapest Direct Flight
$259
Delta Airlines
• nonstop
• 2h 20m
Oct 13
The cheapest nonstop flight from Detroit to Knoxville (DTW-TYS) is currently $259
Fastest Flight
2h 20m
The fastest nonstop flight from Detroit to Knoxville (DTW-TYS) takes 2h 20m
Top Airlines Flying from Detroit to Knoxville
Latest Flight Deals from Detroit (DTW) to Knoxville (TYS)
Compare and book low fare round-trip air tickets from Detroit to Knoxville. Ideal for travelers with confirmed return itineraries.
Oct 25 - Oct 30, Economy
Detroit → Knoxville
7h 35m
4:30 PM - 9:25 PM • 1 stop
Detroit → Knoxville
15h 5m
7:15 AM - 4:20 PM • 1 stop
Southwest Airlines
Oct 25 - Oct 30, Economy
Detroit → Knoxville
13h 50m
10:35 AM - 7:05 PM • 1 stop
Detroit → Knoxville
5h 40m
7:25 PM - 11:05 PM • 1 stop
Southwest Airlines
Oct 25 - Oct 30, Economy
Detroit → Knoxville
15h 45m
1:00 PM - 10:45 PM • 1 stop
Detroit → Knoxville
5h 40m
7:25 PM - 11:05 PM • 1 stop
Southwest Airlines
Oct 25 - Oct 30, Economy
Detroit → Knoxville
2h 20m
4:44 PM - 6:24 PM • nonstop
Detroit → Knoxville
2h 23m
5:18 PM - 7:01 PM • nonstop
Delta Airlines
Oct 25 - Oct 30, Economy
Detroit → Knoxville
8h 54m
5:20 AM - 10:54 AM • 1 stop
Detroit → Knoxville
2h 24m
11:45 AM - 1:29 PM • nonstop
Delta Airlines
Flying to Knoxville soon? We've surfaced some of the most affordable last-minute flights from Detroit to Knoxville, ideal for urgent plans or spontaneous trips.
Oct 13 - Oct 20, Economy
Detroit → Knoxville
2h 20m
8:40 AM - 10:20 AM • nonstop
Detroit → Knoxville
2h 24m
7:26 AM - 9:10 AM • nonstop
Delta Airlines
Oct 13 - Oct 20, Economy
Detroit → Knoxville
2h 20m
4:44 PM - 6:24 PM • nonstop
Detroit → Knoxville
2h 24m
11:45 AM - 1:29 PM • nonstop
Delta Airlines
Oct 13 - Oct 20, Economy
Detroit → Knoxville
6h 55m
9:25 AM - 1:40 PM • 1 stop
Detroit → Knoxville
2h 23m
5:18 PM - 7:01 PM • nonstop
Delta Airlines
Oct 13 - Oct 20, Economy
Detroit → Knoxville
8h 35m
8:25 AM - 1:40 PM • 1 stop
Detroit → Knoxville
2h 24m
11:45 AM - 1:29 PM • nonstop
Delta Airlines
Oct 13 - Oct 20, Economy
Detroit → Knoxville
6h 50m
4:00 PM - 8:10 PM • 1 stop
Detroit → Knoxville
7h 10m
5:15 PM - 9:45 PM • 1 stop
Southwest Airlines
Looking for the fastest way to Knoxville? These direct flight options from DTW to TYS offer both convenience and value—no layovers, just straight to your destination.
Oct 13 - Oct 20, Economy
Detroit → Knoxville
2h 20m
8:40 AM - 10:20 AM • nonstop
Detroit → Knoxville
2h 24m
7:26 AM - 9:10 AM • nonstop
Delta Airlines
Oct 13 - Oct 20, Economy
Detroit → Knoxville
2h 20m
4:44 PM - 6:24 PM • nonstop
Detroit → Knoxville
2h 24m
11:45 AM - 1:29 PM • nonstop
Delta Airlines
Oct 13 - Oct 20, Economy
Detroit → Knoxville
2h 22m
7:55 PM - 9:37 PM • nonstop
Detroit → Knoxville
2h 23m
5:18 PM - 7:01 PM • nonstop
Delta Airlines
Oct 25 - Oct 30, Economy
Detroit → Knoxville
2h 20m
4:44 PM - 6:24 PM • nonstop
Detroit → Knoxville
2h 23m
5:18 PM - 7:01 PM • nonstop
Delta Airlines
Oct 25 - Oct 30, Economy
Detroit → Knoxville
2h 22m
7:55 PM - 9:37 PM • nonstop
Detroit → Knoxville
2h 23m
5:18 PM - 7:01 PM • nonstop
Delta Airlines
FAQs on Detroit to Knoxville Flights
What are the airports in Detroit?
DTW
What’s the most popular airline flying from DTW to TYS?
The most popular airline flying from Detroit to Knoxville are
Can I fly from DTW to TYS non-stop?
Yes, you can fly DTW to TYS non-stop on
Which airlines fly nonstop between Detroit and Knoxville?
The non-stop flights between Detroit and Knoxville are .
What’s the earliest departure time from DTW to TYS Airport?
The earliest flight leaves DTW at 5:20 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Detroit to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from DTW to TYS?
Read the fare rules of the Detroit to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Detroit and Knoxville?
operate flights between Detroit and Knoxville
How long does a flight from Detroit to Knoxville take?
It takes approximately 1 hour to fly non-stop from DTW to TYS, which is 442.92 miles by air.
Which airlines provide the cheapest flights from Detroit (DTW) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from DTW were found on DL : USD 393
Do I need a passport to fly between DTW and TYS?
No
What’s the latest departure time from DTW to TYS ?
The last flight leaves DTW at 7:55 pm
Detroit (DTW) to Knoxville (TYS): Airport Information
| Origin Airport | Detroit Metropolitan Wayne County , Detroit, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 443 miles |
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