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Uncover the best deals on Detroit to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest DTW - TYS Flights
Useful information for finding best airline tickets from Detroit Metropolitan Wayne County to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$294
Southwest Airlines
• 1 stop
• 10h 20m
Dec 16 – Dec 16
The cheapest round trip flight from Detroit to Knoxville (DTW-TYS-DTW) is currently $294
Cheapest Direct Flight
$487
Delta Airlines
• nonstop
• 2h 17m
Mar 08
The cheapest nonstop flight from Detroit to Knoxville (DTW-TYS) is currently $487
Fastest Flight
2h 15m
The fastest nonstop flight from Detroit to Knoxville (DTW-TYS) takes 2h 15m
Latest Flight Deals from Detroit (DTW) to Knoxville (TYS)
Compare and book low fare round-trip air tickets from Detroit to Knoxville. Ideal for travelers with confirmed return itineraries.
Dec 16 - Dec 16, Economy
Detroit → Knoxville
10h 20m
6:00 AM - 12:20 PM • 1 stop
Detroit → Knoxville
43h 40m
5:15 PM - 7:35 PM • 1 stop
Southwest Airlines
Dec 16 - Dec 17, Economy
Detroit → Knoxville
10h 25m
1:25 PM - 7:50 PM • 1 stop
Detroit → Knoxville
5h 30m
7:25 PM - 10:55 PM • 1 stop
Southwest Airlines
Dec 16 - Dec 17, Economy
Detroit → Knoxville
10h 25m
1:25 PM - 7:50 PM • 1 stop
Detroit → Knoxville
13h 35m
12:50 PM - 9:05 PM • 2 stops
Southwest Airlines
Dec 16 - Dec 16, Economy
Detroit → Knoxville
2h 26m
8:30 AM - 10:16 AM • nonstop
Detroit → Knoxville
2h 22m
5:10 PM - 6:52 PM • nonstop
Delta Airlines
Dec 16 - Dec 16, Economy
Detroit → Knoxville
8h 22m
6:25 AM - 11:27 AM • 1 stop
Detroit → Knoxville
2h 22m
5:10 PM - 6:52 PM • nonstop
Delta Airlines
Looking for the fastest way to Knoxville? These direct flight options from DTW to TYS offer both convenience and value—no layovers, just straight to your destination.
Mar 08 - Mar 15, Economy
Detroit → Knoxville
2h 17m
3:50 PM - 5:27 PM • nonstop
Detroit → Knoxville
2h 25m
5:15 PM - 7:00 PM • nonstop
Delta Airlines
Mar 08 - Mar 15, Economy
Detroit → Knoxville
2h 24m
8:30 AM - 10:14 AM • nonstop
Detroit → Knoxville
2h 28m
7:30 AM - 9:18 AM • nonstop
Delta Airlines
Mar 08 - Mar 15, Economy
Detroit → Knoxville
2h 19m
7:55 PM - 9:34 PM • nonstop
Detroit → Knoxville
2h 24m
11:30 AM - 1:14 PM • nonstop
Delta Airlines
Dec 16 - Dec 16, Economy
Detroit → Knoxville
2h 26m
8:30 AM - 10:16 AM • nonstop
Detroit → Knoxville
2h 22m
5:10 PM - 6:52 PM • nonstop
Delta Airlines
Dec 16 - Dec 17, Economy
Detroit → Knoxville
2h 19m
4:43 PM - 6:22 PM • nonstop
Detroit → Knoxville
2h 30m
11:49 AM - 1:39 PM • nonstop
Delta Airlines
FAQs on Detroit to Knoxville Flights
What are the airports in Detroit?
DTW
What’s the most popular airline flying from DTW to TYS?
The most popular airline flying from Detroit to Knoxville are
Can I fly from DTW to TYS non-stop?
Yes, you can fly DTW to TYS non-stop on
Which airlines fly nonstop between Detroit and Knoxville?
The non-stop flights between Detroit and Knoxville are .
What’s the earliest departure time from DTW to TYS Airport?
The earliest flight leaves DTW at 6:00 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Detroit to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from DTW to TYS?
Read the fare rules of the Detroit to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Detroit and Knoxville?
operate flights between Detroit and Knoxville
How long does a flight from Detroit to Knoxville take?
It takes approximately 1 hour to fly non-stop from DTW to TYS, which is 442.92 miles by air.
Which airlines provide the cheapest flights from Detroit (DTW) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from DTW were found on DL : USD 733
Do I need a passport to fly between DTW and TYS?
No
What’s the latest departure time from DTW to TYS ?
The last flight leaves DTW at 7:58 pm
Detroit (DTW) to Knoxville (TYS): Airport Information
| Origin Airport | Detroit Metropolitan Wayne County , Detroit, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 443 miles |
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