Lowest Prices
Uncover the best deals on Detroit to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest DTW - TYS Flights
Useful information for finding best airline tickets from Detroit Metropolitan Wayne County to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$246
Delta Airlines
• nonstop
• 2h 19m
Aug 10 – Aug 17
The cheapest round trip flight from Detroit to Knoxville (DTW-TYS-DTW) is currently $246
Cheapest Direct Flight
$305
Delta Airlines
• nonstop
• 2h 19m
Aug 10
The cheapest nonstop flight from Detroit to Knoxville (DTW-TYS) is currently $305
Fastest Flight
2h 19m
The fastest nonstop flight from Detroit to Knoxville (DTW-TYS) takes 2h 19m
Top Airlines Flying from Detroit to Knoxville
Latest Flight Deals from Detroit (DTW) to Knoxville (TYS)
Compare and book low fare round-trip air tickets from Detroit to Knoxville. Ideal for travelers with confirmed return itineraries.
Aug 10 - Aug 17, Economy
Detroit → Knoxville
2h 19m
7:55 PM - 9:34 PM • nonstop
Detroit → Knoxville
8h 38m
7:41 PM - 12:59 AM • 1 stop
Delta Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
14h 5m
11:10 AM - 7:55 PM • 2 stops
Detroit → Knoxville
8h 45m
7:10 AM - 12:35 PM • 1 stop
Southwest Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
13h 35m
8:55 AM - 5:10 PM • 2 stops
Detroit → Knoxville
7h 30m
5:45 PM - 10:35 PM • 1 stop
Southwest Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
10h 25m
5:55 AM - 12:20 PM • 1 stop
Detroit → Knoxville
16h 50m
8:25 AM - 6:35 PM • 3 stops
Southwest Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
10h 14m
7:20 AM - 1:34 PM • 1 stop
Detroit → Knoxville
8h 38m
7:41 PM - 12:59 AM • 1 stop
Delta Airlines
Flying to Knoxville soon? We've surfaced some of the most affordable last-minute flights from Detroit to Knoxville, ideal for urgent plans or spontaneous trips.
Aug 10 - Aug 17, Economy
Detroit → Knoxville
2h 19m
7:55 PM - 9:34 PM • nonstop
Detroit → Knoxville
8h 38m
7:41 PM - 12:59 AM • 1 stop
Delta Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
14h 5m
11:10 AM - 7:55 PM • 2 stops
Detroit → Knoxville
8h 45m
7:10 AM - 12:35 PM • 1 stop
Southwest Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
13h 35m
8:55 AM - 5:10 PM • 2 stops
Detroit → Knoxville
7h 30m
5:45 PM - 10:35 PM • 1 stop
Southwest Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
10h 25m
5:55 AM - 12:20 PM • 1 stop
Detroit → Knoxville
16h 50m
8:25 AM - 6:35 PM • 3 stops
Southwest Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
10h 14m
7:20 AM - 1:34 PM • 1 stop
Detroit → Knoxville
8h 38m
7:41 PM - 12:59 AM • 1 stop
Delta Airlines
Looking for the fastest way to Knoxville? These direct flight options from DTW to TYS offer both convenience and value—no layovers, just straight to your destination.
Aug 10 - Aug 17, Economy
Detroit → Knoxville
2h 19m
7:55 PM - 9:34 PM • nonstop
Detroit → Knoxville
2h 24m
11:38 AM - 1:22 PM • nonstop
Delta Airlines
Sep 22 - Sep 25, Economy
Detroit → Knoxville
2h 19m
8:05 PM - 9:44 PM • nonstop
Detroit → Knoxville
2h 24m
5:28 PM - 7:12 PM • nonstop
Delta Airlines
Sep 22 - Sep 25, Economy
Detroit → Knoxville
2h 23m
8:35 AM - 10:18 AM • nonstop
Detroit → Knoxville
2h 24m
5:28 PM - 7:12 PM • nonstop
Delta Airlines
Sep 22 - Sep 25, Economy
Detroit → Knoxville
2h 19m
3:59 PM - 5:38 PM • nonstop
Detroit → Knoxville
2h 22m
7:33 AM - 9:15 AM • nonstop
Delta Airlines
Aug 10 - Aug 17, Economy
Detroit → Knoxville
2h 22m
4:00 PM - 5:42 PM • nonstop
Detroit → Knoxville
2h 24m
11:38 AM - 1:22 PM • nonstop
Delta Airlines
FAQs on Detroit to Knoxville Flights
What are the airports in Detroit?
DTW
What’s the most popular airline flying from DTW to TYS?
The most popular airline flying from Detroit to Knoxville are
Can I fly from DTW to TYS non-stop?
Yes, you can fly DTW to TYS non-stop on
Which airlines fly nonstop between Detroit and Knoxville?
The non-stop flights between Detroit and Knoxville are .
What’s the earliest departure time from DTW to TYS Airport?
The earliest flight leaves DTW at 5:55 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Detroit to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from DTW to TYS?
Read the fare rules of the Detroit to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Detroit and Knoxville?
operate flights between Detroit and Knoxville
How long does a flight from Detroit to Knoxville take?
It takes approximately 1 hour to fly non-stop from DTW to TYS, which is 442.92 miles by air.
Which airlines provide the cheapest flights from Detroit (DTW) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from DTW were found on DL : USD 616
Do I need a passport to fly between DTW and TYS?
No
What’s the latest departure time from DTW to TYS ?
The last flight leaves DTW at 8:05 pm
Detroit (DTW) to Knoxville (TYS): Airport Information
| Origin Airport | Detroit Metropolitan Wayne County , Detroit, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 443 miles |
More Flight Options for Detroit (DTW) and Knoxville (TYS)
Flights from Detroit (DTW)
to Orlando (MCO)
Flights from Detroit (DTW)
to Fort Myers (RSW)
Flights from Detroit (DTW)
to Las Vegas (LAS)
Flights from Detroit (DTW)
to Nashville (BNA)
Flights from Detroit (DTW)
to Dallas (DAL)
Flights from Detroit (DTW)
to Myrtle Beach (MYR)
Flights from Detroit (DTW)
to Miami (MIA)
Flights from Detroit (DTW)
to Atlanta (ATL)
Flights from Detroit (DTW)
to Denver (DEN)
Flights from Detroit (DTW)
to Kansas City (MCI)
Flights from Detroit (DTW)
to Dallas (DFW)
Flights from Detroit (DTW)
to Dallas (DFW)
Flights from Detroit (DTW)
to Hartford (BDL)
Flights from Detroit (DTW)
to Hartford (BDL)
Flights from Detroit (DTW)
to New York (LGA)
Flights from Detroit (DTW)
to Boston (BOS)
Flights from Detroit (DTW)
to Fort Lauderdale (FLL)
Flights from Detroit (DTW)
to Tampa (TPA)
Flights from Detroit (DTW)
to Philadelphia (PHL)
Flights from Detroit (DTW)
to Memphis (MEM)
Flights from Baltimore (BWI)
to Knoxville (TYS)
Flights from Hartford (BDL)
to Knoxville (TYS)
Flights from Minneapolis (MSP)
to Knoxville (TYS)
Flights from Minneapolis (MSP)
to Knoxville (TYS)
Flights from Portland (PDX)
to Knoxville (TYS)
Flights from Montego Bay (MBJ)
to Knoxville (TYS)
Flights from Seattle (SEA)
to Knoxville (TYS)
Flights from Chicago (MDW)
to Knoxville (TYS)
Flights from Tampa (TPA)
to Knoxville (TYS)
Flights from Portland (PWM)
to Knoxville (TYS)
Flights from Ontario (ONT)
to Knoxville (TYS)
Flights from Ontario (ONT)
to Knoxville (TYS)
Flights from Chicago (ORD)
to Knoxville (TYS)
Flights from Denver (DEN)
to Knoxville (TYS)
Flights from Detroit (DTW)
to Knoxville (TYS)
Flights from Boston (BOS)
to Knoxville (TYS)
Flights from Houston (IAH)
to Knoxville (TYS)
Flights from Dallas (DFW)
to Knoxville (TYS)
Flights from Dallas (DFW)
to Knoxville (TYS)
Flights from Austin (AUS)
to Knoxville (TYS)
Cheap flights to North America (NA)
Cheap flights to United States (US)
Cheap flights to Tennessee (US-TN)
Cheap flights to Michigan (US-MI)
Cheap flights from North America (NA)
Cheap flights from United States (US)
Cheap flights from Tennessee (US-TN)
Cheap flights from Michigan (US-MI)
Flights to Detroit (DTW)
Flights to Knoxville (TYS)
Flights from Detroit (DTW)
Flights from Knoxville (TYS)
Flights from Knoxville (TYS)
to Detroit (DTW)
Why Fareleaders for DTW to TYS Plane Tickets
New Deals Everyday
Get the best prices on DTW to TYS flights—we update our fares daily so you never miss a saving.
No Service Fees
Compare hundreds of Detroit to Knoxville flights and secure the best deals—we never add any service fees.