Cheap Flight Tickets from San Diego (SAN) to Knoxville (TYS), Starting at $423

Good to Know: Cheapest and Fastest SAN - TYS Flights

Useful information for finding best airline tickets from San Diego International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$423

DL Delta Airlines • 1 stop • 13h 47m

Aug 27 – Sep 03

The cheapest round trip flight from San Diego to Knoxville (SAN-TYS-SAN) is currently $423

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Fastest Flight

13h 47m

The fastest nonstop flight from San Diego to Knoxville (SAN-TYS) takes 13h 47m

Latest Flight Deals from San Diego (SAN) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from San Diego to Knoxville. Ideal for travelers with confirmed return itineraries.

Aug 27 - Sep 03, Economy
DL
San Diego → Knoxville
13h 47m
6:15 AM - 5:42 PM • 1 stop
DL
San Diego → Knoxville
22h 16m
7:30 AM - 6:06 PM • 2 stops
$423
Delta Airlines
Aug 27 - Sep 03, Economy
DL
San Diego → Knoxville
40h 1m
7:59 PM - 11:00 PM • 2 stops
DL
San Diego → Knoxville
15h 55m
7:15 AM - 2:10 PM • 1 stop
$433
Delta Airlines
Aug 27 - Sep 03, Economy
WN
San Diego → Knoxville
17h
10:40 PM - 12:00 PM • 1 stop
WN
San Diego → Knoxville
13h 35m
4:50 PM - 10:05 PM • 1 stop
$663
Southwest Airlines
Aug 20 - Aug 23, Economy
WN
San Diego → Knoxville
17h 20m
10:40 PM - 12:20 PM • 1 stop
WN
San Diego → Knoxville
13h 30m
5:55 PM - 11:05 PM • 1 stop
$740
Southwest Airlines
Aug 20 - Aug 23, Economy
WN
San Diego → Knoxville
22h 35m
7:25 PM - 12:20 PM • 2 stops
WN
San Diego → Knoxville
14h
3:35 PM - 9:15 PM • 1 stop
$746
Southwest Airlines
Aug 20 - Aug 23, Economy
WN
San Diego → Knoxville
23h 25m
7:15 PM - 12:20 PM • 2 stops
WN
San Diego → Knoxville
14h
3:35 PM - 9:15 PM • 1 stop
$746
Southwest Airlines

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Looking for a cheap last-minute deal or the best round-trip flight from San Diego to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on San Diego to Knoxville Flights

What are the airports in San Diego?
SAN
What’s the most popular airline flying from SAN to TYS?
The most popular airline flying from San Diego to Knoxville are
Can I fly from SAN to TYS non-stop?
NO
Which airlines fly nonstop between San Diego and Knoxville?
The non-stop flights between San Diego and Knoxville are .
What’s the earliest departure time from SAN to TYS Airport?
The earliest flight leaves SAN at 6:15 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my San Diego to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from SAN to TYS?
Read the fare rules of the San Diego to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from San Diego and Knoxville?
operate flights between San Diego and Knoxville
How long does a flight from San Diego to Knoxville take?
It takes approximately 4 hour to fly non-stop from SAN to TYS, which is 1902.22 miles by air.
Which airlines provide the cheapest flights from San Diego (SAN) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from SAN were found on WN : USD 740
Do I need a passport to fly between SAN and TYS?
No
What’s the latest departure time from SAN to TYS ?
The last flight leaves SAN at 10:40 pm

San Diego (SAN) to Knoxville (TYS): Airport Information

Origin Airport San Diego International , San Diego, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 1902 miles

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