Cheap Flight Tickets from San Diego (SAN) to Knoxville (TYS), Starting at $275

Good to Know: Cheapest and Fastest SAN - TYS Flights

Useful information for finding best airline tickets from San Diego International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$275

WN Southwest Airlines • 2 stops • 12h 15m

Dec 27 – Dec 31

The cheapest round trip flight from San Diego to Knoxville (SAN-TYS-SAN) is currently $275

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Fastest Flight

12h 15m

The fastest nonstop flight from San Diego to Knoxville (SAN-TYS) takes 12h 15m

Top Airlines Flying from San Diego to Knoxville

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Alaska Airlines -AS

Alaska Airlines

Latest Flight Deals from San Diego (SAN) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from San Diego to Knoxville. Ideal for travelers with confirmed return itineraries.

Dec 27 - Dec 31, Economy
WN
San Diego → Knoxville
12h 15m
8:05 AM - 6:40 PM • 2 stops
WN
San Diego → Knoxville
10h 30m
7:05 AM - 10:35 AM • 1 stop
$275
Southwest Airlines
Dec 27 - Dec 31, Economy
WN
San Diego → Knoxville
21h 55m
7:50 PM - 12:05 PM • 2 stops
WN
San Diego → Knoxville
14h 15m
5:15 PM - 11:10 PM • 1 stop
$335
Southwest Airlines
Dec 27 - Dec 31, Economy
DL
San Diego → Knoxville
16h 46m
10:30 PM - 11:36 AM • 1 stop
DL
San Diego → Knoxville
37h 16m
2:19 PM - 9:55 AM • 1 stop
$752
Delta Airlines
Dec 26 - Dec 30, Economy
DL
San Diego → Knoxville
20h 5m
6:25 AM - 9:30 PM • 2 stops
DL
San Diego → Knoxville
13h 45m
6:50 AM - 12:15 PM • 1 stop
$890
Delta Airlines
Dec 26 - Dec 30, Economy
DL
San Diego → Knoxville
17h 10m
6:30 AM - 8:00 PM • 1 stop
DL
San Diego → Knoxville
13h 45m
6:50 AM - 12:15 PM • 1 stop
$965
Delta Airlines
Dec 26 - Dec 30, Economy
DL
San Diego → Knoxville
14h 1m
9:50 PM - 9:31 AM • 1 stop
DL
San Diego → Knoxville
13h 45m
6:50 AM - 12:15 PM • 1 stop
$1011
Delta Airlines

Fly from San Diego to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from San Diego to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on San Diego to Knoxville Flights

What are the airports in San Diego?
SAN
What’s the most popular airline flying from SAN to TYS?
The most popular airline flying from San Diego to Knoxville are
Can I fly from SAN to TYS non-stop?
NO
Which airlines fly nonstop between San Diego and Knoxville?
The non-stop flights between San Diego and Knoxville are .
What’s the earliest departure time from SAN to TYS Airport?
The earliest flight leaves SAN at 6:25 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my San Diego to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from SAN to TYS?
Read the fare rules of the San Diego to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from San Diego and Knoxville?
operate flights between San Diego and Knoxville
How long does a flight from San Diego to Knoxville take?
It takes approximately 4 hour to fly non-stop from SAN to TYS, which is 1902.22 miles by air.
Which airlines provide the cheapest flights from San Diego (SAN) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from SAN were found on DL : USD 752
Do I need a passport to fly between SAN and TYS?
No
What’s the latest departure time from SAN to TYS ?
The last flight leaves SAN at 10:30 pm

San Diego (SAN) to Knoxville (TYS): Airport Information

Origin Airport San Diego International , San Diego, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 1902 miles

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