Cheap Flight Tickets from Chicago (MDW) to Knoxville (TYS), Starting at $282

Good to Know: Cheapest and Fastest MDW - TYS Flights

Useful information for finding best airline tickets from Chicago Midway International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$446

DL Delta Airlines • 1 stop • 5h 50m

Oct 25 – Oct 29

The cheapest round trip flight from Chicago to Knoxville (MDW-TYS-MDW) is currently $446

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Cheapest Direct Flight

$282

AA American Airlines • nonstop • 2h 31m

Oct 26

The cheapest nonstop flight from Chicago to Knoxville (MDW-TYS) is currently $282

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Fastest Flight

2h 25m

The fastest nonstop flight from Chicago to Knoxville (MDW-TYS) takes 2h 25m

Top Airlines Flying from Chicago to Knoxville

Delta Airline, DL

Delta Airlines

Southwest Airlines-WN

Southwest Airlines

United Airlines, UA

United Airlines

WestJet Airlines

WestJet Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Chicago (MDW) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from Chicago to Knoxville. Ideal for travelers with confirmed return itineraries.

Oct 25 - Oct 29, Economy
DL
Chicago → Knoxville
5h 50m
6:04 AM - 10:54 AM • 1 stop
DL
Chicago → Knoxville
8h 28m
12:06 PM - 4:14 PM • 1 stop
$446
Delta Airlines
Oct 25 - Oct 29, Economy
DL
Chicago → Knoxville
10h 36m
6:04 AM - 1:40 PM • 1 stop
DL
Chicago → Knoxville
8h 30m
6:23 PM - 10:33 PM • 1 stop
$501
Delta Airlines
Oct 25 - Oct 29, Economy
DL
Chicago → Knoxville
17h 4m
6:04 AM - 5:28 PM • 1 stop
DL
Chicago → Knoxville
10h 45m
10:29 AM - 4:14 PM • 1 stop
$566
Delta Airlines
Oct 25 - Oct 29, Economy
DL
Chicago → Knoxville
10h 48m
10:59 AM - 6:47 PM • 1 stop
DL
Chicago → Knoxville
10h 21m
7:26 AM - 12:47 PM • 1 stop
$707
Delta Airlines
Oct 25 - Oct 29, Economy
DL
Chicago → Knoxville
7h 11m
5:31 PM - 11:02 PM • 1 stop
DL
Chicago → Knoxville
8h 28m
12:06 PM - 4:14 PM • 1 stop
$707
Delta Airlines
Oct 25 - Oct 29, Economy
DL
Chicago → Knoxville
7h 38m
12:49 PM - 6:47 PM • 1 stop
DL
Chicago → Knoxville
10h 45m
10:29 AM - 4:14 PM • 1 stop
$797
Delta Airlines

Fly from Chicago to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Chicago to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Chicago to Knoxville Flights

What are the airports in Chicago?
ORD,MDW
What’s the most popular airline flying from MDW to TYS?
The most popular airline flying from Chicago to Knoxville are
Can I fly from MDW to TYS non-stop?
Yes, you can fly MDW to TYS non-stop on
Which airlines fly nonstop between Chicago and Knoxville?
The non-stop flights between Chicago and Knoxville are .
What’s the earliest departure time from MDW to TYS Airport?
The earliest flight leaves MDW at 6:04 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Chicago to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from MDW to TYS?
Read the fare rules of the Chicago to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Chicago and Knoxville?
operate flights between Chicago and Knoxville
How long does a flight from Chicago to Knoxville take?
It takes approximately 2 hour to fly non-stop from MDW to TYS, which is 459.25 miles by air.
Which airlines provide the cheapest flights from Chicago (MDW) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from MDW were found on DL : USD 707
Do I need a passport to fly between MDW and TYS?
No
What’s the latest departure time from MDW to TYS ?
The last flight leaves MDW at 9:05 pm

Chicago (MDW) to Knoxville (TYS): Airport Information

Origin Airport Chicago Midway International , Chicago, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 459 miles

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