Cheap Flight Tickets from Chicago (MDW) to Knoxville (TYS), Starting at $303

Good to Know: Cheapest and Fastest MDW - TYS Flights

Useful information for finding best airline tickets from Chicago Midway International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$310

WN Southwest Airlines • 1 stop • 12h 15m

Dec 22 – Dec 27

The cheapest round trip flight from Chicago to Knoxville (MDW-TYS-MDW) is currently $310

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Cheapest Direct Flight

$303

G4 Allegiant • nonstop • 3h 45m

Oct 02

The cheapest nonstop flight from Chicago to Knoxville (MDW-TYS) is currently $303

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Fastest Flight

3h 45m

The fastest nonstop flight from Chicago to Knoxville (MDW-TYS) takes 3h 45m

Top Airlines Flying from Chicago to Knoxville

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

Latest Flight Deals from Chicago (MDW) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from Chicago to Knoxville. Ideal for travelers with confirmed return itineraries.

Dec 22 - Dec 27, Economy
WN
Chicago → Knoxville
12h 15m
1:05 PM - 9:40 PM • 1 stop
WN
Chicago → Knoxville
12h 15m
3:45 PM - 10:20 PM • 1 stop
$310
Southwest Airlines
Dec 22 - Dec 27, Economy
WN
Chicago → Knoxville
7h 15m
4:05 PM - 9:40 PM • 1 stop
WN
Chicago → Knoxville
15h
3:45 PM - 11:45 PM • 1 stop
$310
Southwest Airlines
Dec 22 - Dec 27, Economy
DL
Chicago → Knoxville
10h 39m
6:00 AM - 1:39 PM • 1 stop
DL
Chicago → Knoxville
6h 50m
9:00 AM - 12:10 PM • 1 stop
$388
Delta Airlines
Dec 22 - Dec 27, Economy
WN
Chicago → Knoxville
12h 15m
1:05 PM - 9:40 PM • 2 stops
WN
Chicago → Knoxville
8h 35m
8:00 AM - 12:15 PM • 1 stop
$445
Southwest Airlines
Dec 22 - Dec 27, Economy
WN
Chicago → Knoxville
14h 5m
12:50 PM - 10:35 PM • 1 stop
WN
Chicago → Knoxville
8h 35m
8:00 AM - 12:15 PM • 1 stop
$485
Southwest Airlines
Dec 22 - Dec 27, Economy
WN
Chicago → Knoxville
7h 15m
4:05 PM - 9:40 PM • 1 stop
WN
Chicago → Knoxville
13h 45m
7:00 AM - 2:25 PM • 2 stops
$486
Southwest Airlines

Fly from Chicago to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Chicago to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Chicago to Knoxville Flights

What are the airports in Chicago?
ORD,MDW
What’s the most popular airline flying from MDW to TYS?
The most popular airline flying from Chicago to Knoxville are
Can I fly from MDW to TYS non-stop?
Yes, you can fly MDW to TYS non-stop on
Which airlines fly nonstop between Chicago and Knoxville?
The non-stop flights between Chicago and Knoxville are .
What’s the earliest departure time from MDW to TYS Airport?
The earliest flight leaves MDW at 6:00 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Chicago to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from MDW to TYS?
Read the fare rules of the Chicago to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Chicago and Knoxville?
operate flights between Chicago and Knoxville
How long does a flight from Chicago to Knoxville take?
It takes approximately 2 hour to fly non-stop from MDW to TYS, which is 459.25 miles by air.
Which airlines provide the cheapest flights from Chicago (MDW) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from MDW were found on WN : USD 486
Do I need a passport to fly between MDW and TYS?
No
What’s the latest departure time from MDW to TYS ?
The last flight leaves MDW at 4:05 pm

Chicago (MDW) to Knoxville (TYS): Airport Information

Origin Airport Chicago Midway International , Chicago, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 459 miles

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