Lowest Prices
Uncover the best deals on Orlando to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest MCO - TYS Flights
Useful information for finding best airline tickets from Orlando International to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$173
Frontier Airlines
• 1 stop
• 50h 17m
Jul 21 – Jul 24
The cheapest round trip flight from Orlando to Knoxville (MCO-TYS-MCO) is currently $173
Cheapest Direct Flight
$537
Southwest Airlines
• nonstop
• 2h 30m
Jul 21
The cheapest nonstop flight from Orlando to Knoxville (MCO-TYS) is currently $537
Fastest Flight
2h 30m
The fastest nonstop flight from Orlando to Knoxville (MCO-TYS) takes 2h 30m
Top Airlines Flying from Orlando to Knoxville
Latest Flight Deals from Orlando (MCO) to Knoxville (TYS)
Compare and book low fare round-trip air tickets from Orlando to Knoxville. Ideal for travelers with confirmed return itineraries.
Jul 21 - Jul 24, Economy
Orlando → Knoxville
50h 17m
1:07 PM - 7:24 PM • 1 stop
Orlando → Knoxville
25h 28m
8:19 PM - 11:47 AM • 1 stop
Frontier Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
5h 55m
8:10 AM - 12:05 PM • 1 stop
Orlando → Knoxville
5h 50m
7:45 PM - 11:35 PM • 1 stop
Southwest Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
8h 25m
4:15 PM - 9:20 PM • 1 stop
Orlando → Knoxville
8h 40m
7:30 AM - 12:50 PM • 1 stop
Southwest Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
5h 43m
11:05 AM - 2:48 PM • 1 stop
Orlando → Knoxville
5h 16m
5:40 AM - 8:56 AM • 1 stop
Delta Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
7h 12m
3:40 PM - 8:12 PM • 1 stop
Orlando → Knoxville
5h 16m
5:40 AM - 8:56 AM • 1 stop
Delta Airlines
Flying to Knoxville soon? We've surfaced some of the most affordable last-minute flights from Orlando to Knoxville, ideal for urgent plans or spontaneous trips.
Jul 21 - Jul 24, Economy
Orlando → Knoxville
50h 17m
1:07 PM - 7:24 PM • 1 stop
Orlando → Knoxville
25h 28m
8:19 PM - 11:47 AM • 1 stop
Frontier Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
5h 55m
8:10 AM - 12:05 PM • 1 stop
Orlando → Knoxville
5h 50m
7:45 PM - 11:35 PM • 1 stop
Southwest Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
8h 25m
4:15 PM - 9:20 PM • 1 stop
Orlando → Knoxville
8h 40m
7:30 AM - 12:50 PM • 1 stop
Southwest Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
5h 43m
11:05 AM - 2:48 PM • 1 stop
Orlando → Knoxville
5h 16m
5:40 AM - 8:56 AM • 1 stop
Delta Airlines
Jul 21 - Jul 24, Economy
Orlando → Knoxville
7h 12m
3:40 PM - 8:12 PM • 1 stop
Orlando → Knoxville
5h 16m
5:40 AM - 8:56 AM • 1 stop
Delta Airlines
Looking for the fastest way to Knoxville? These direct flight options from MCO to TYS offer both convenience and value—no layovers, just straight to your destination.
FAQs on Orlando to Knoxville Flights
What are the airports in Orlando?
MCO
What’s the most popular airline flying from MCO to TYS?
The most popular airline flying from Orlando to Knoxville are
Can I fly from MCO to TYS non-stop?
Yes, you can fly MCO to TYS non-stop on
Which airlines fly nonstop between Orlando and Knoxville?
The non-stop flights between Orlando and Knoxville are .
What’s the earliest departure time from MCO to TYS Airport?
The earliest flight leaves MCO at 8:10 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Orlando to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from MCO to TYS?
Read the fare rules of the Orlando to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Orlando and Knoxville?
operate flights between Orlando and Knoxville
How long does a flight from Orlando to Knoxville take?
It takes approximately 2 hour to fly non-stop from MCO to TYS, which is 532.36 miles by air.
Which airlines provide the cheapest flights from Orlando (MCO) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from MCO were found on DL : USD 686
Do I need a passport to fly between MCO and TYS?
No
What’s the latest departure time from MCO to TYS ?
The last flight leaves MCO at 4:15 pm
Orlando (MCO) to Knoxville (TYS): Airport Information
| Origin Airport | Orlando International , Orlando, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 532 miles |
More Flight Options for Orlando (MCO) and Knoxville (TYS)
Flights from Orlando (MCO)
to San Juan (SJU)
Flights from Orlando (MCO)
to Las Vegas (LAS)
Flights from Orlando (MCO)
to Philadelphia (PHL)
Flights from Orlando (MCO)
to Chicago (ORD)
Flights from Orlando (MCO)
to Atlanta (ATL)
Flights from Orlando (MCO)
to Denver (DEN)
Flights from Orlando (MCO)
to White Plains (HPN)
Flights from Orlando (MCO)
to Miami (MIA)
Flights from Orlando (MCO)
to New York (JFK)
Flights from Orlando (MCO)
to Los Angeles (LAX)
Flights from Orlando (MCO)
to Phoenix (PHX)
Flights from Orlando (MCO)
to San Antonio (SAT)
Flights from Orlando (MCO)
to Albany (ALB)
Flights from Orlando (MCO)
to San Francisco (SFO)
Flights from Orlando (MCO)
to Seattle (SEA)
Flights from Orlando (MCO)
to Baltimore (BWI)
Flights from Orlando (MCO)
to Baltimore (BWI)
Flights from Orlando (MCO)
to Boston (BOS)
Flights from Orlando (MCO)
to Houston (HOU)
Flights from Orlando (MCO)
to Newark (EWR)
Flights from Orlando (MCO)
to Knoxville (TYS)
Flights from Denver (DEN)
to Knoxville (TYS)
Flights from Houston (HOU)
to Knoxville (TYS)
Flights from Cleveland (CLE)
to Knoxville (TYS)
Flights from Memphis (MEM)
to Knoxville (TYS)
Flights from Charleston (CHS)
to Knoxville (TYS)
Flights from Portland (PDX)
to Knoxville (TYS)
Flights from Buffalo (BUF)
to Knoxville (TYS)
Flights from Seattle (SEA)
to Knoxville (TYS)
Flights from Milwaukee (MKE)
to Knoxville (TYS)
Flights from Oklahoma City (OKC)
to Knoxville (TYS)
Flights from Ontario (ONT)
to Knoxville (TYS)
Flights from Ontario (ONT)
to Knoxville (TYS)
Flights from Austin (AUS)
to Knoxville (TYS)
Flights from San Antonio (SAT)
to Knoxville (TYS)
Flights from St Louis (STL)
to Knoxville (TYS)
Flights from Chicago (MDW)
to Knoxville (TYS)
Flights from Dallas (DFW)
to Knoxville (TYS)
Flights from Dallas (DFW)
to Knoxville (TYS)
Flights from Myrtle Beach (MYR)
to Knoxville (TYS)
Cheap flights to North America (NA)
Cheap flights to United States (US)
Cheap flights to Florida (US-FL)
Cheap flights to Tennessee (US-TN)
Cheap flights from North America (NA)
Cheap flights from United States (US)
Cheap flights from Florida (US-FL)
Cheap flights from Tennessee (US-TN)
Flights to Orlando (MCO)
Flights to Knoxville (TYS)
Flights from Orlando (MCO)
Flights from Knoxville (TYS)
Flights from Knoxville (TYS)
to Orlando (MCO)
Why Fareleaders for MCO to TYS Plane Tickets
New Deals Everyday
Get the best prices on MCO to TYS flights—we update our fares daily so you never miss a saving.
No Service Fees
Compare hundreds of Orlando to Knoxville flights and secure the best deals—we never add any service fees.