Lowest Prices
Uncover the best deals on Tampa to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest TPA - TYS Flights
Useful information for finding best airline tickets from Tampa International to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$342
Southwest Airlines
• 2 stops
• 34h 5m
Nov 14 – Nov 16
The cheapest round trip flight from Tampa to Knoxville (TPA-TYS-TPA) is currently $342
Fastest Flight
5h 55m
The fastest nonstop flight from Tampa to Knoxville (TPA-TYS) takes 5h 55m
Top Airlines Flying from Tampa to Knoxville
Latest Flight Deals from Tampa (TPA) to Knoxville (TYS)
Compare and book low fare round-trip air tickets from Tampa to Knoxville. Ideal for travelers with confirmed return itineraries.
Nov 14 - Nov 16, Economy
Tampa → Knoxville
34h 5m
3:25 PM - 12:10 PM • 2 stops
Tampa → Knoxville
32h 5m
5:15 PM - 12:40 PM • 2 stops
Southwest Airlines
Nov 14 - Nov 16, Economy
Tampa → Knoxville
12h 5m
10:20 AM - 5:45 PM • 1 stop
Tampa → Knoxville
14h 10m
7:05 AM - 3:55 PM • 1 stop
Southwest Airlines
Nov 14 - Nov 16, Economy
Tampa → Knoxville
15h 30m
8:15 AM - 5:45 PM • 2 stops
Tampa → Knoxville
7h 20m
5:15 PM - 9:55 PM • 1 stop
Southwest Airlines
Nov 14 - Nov 16, Economy
Tampa → Knoxville
12h 25m
6:25 AM - 2:10 PM • 2 stops
Tampa → Knoxville
7h 20m
5:15 PM - 9:55 PM • 1 stop
Southwest Airlines
Nov 13 - Nov 13, Economy
Tampa → Knoxville
8h 38m
6:10 AM - 11:28 AM • 1 stop
Tampa → Knoxville
10h 18m
6:07 PM - 12:25 AM • 1 stop
Delta Airlines
FAQs on Tampa to Knoxville Flights
What are the airports in Tampa?
TPA
What’s the most popular airline flying from TPA to TYS?
The most popular airline flying from Tampa to Knoxville are
Can I fly from TPA to TYS non-stop?
NO
Which airlines fly nonstop between Tampa and Knoxville?
The non-stop flights between Tampa and Knoxville are .
What’s the earliest departure time from TPA to TYS Airport?
The earliest flight leaves TPA at 6:10 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Tampa to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TPA to TYS?
Read the fare rules of the Tampa to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Tampa and Knoxville?
operate flights between Tampa and Knoxville
How long does a flight from Tampa to Knoxville take?
It takes approximately 2 hour to fly non-stop from TPA to TYS, which is 546.64 miles by air.
Which airlines provide the cheapest flights from Tampa (TPA) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from TPA were found on WN : USD 355
Do I need a passport to fly between TPA and TYS?
No
What’s the latest departure time from TPA to TYS ?
The last flight leaves TPA at 3:25 pm
Tampa (TPA) to Knoxville (TYS): Airport Information
| Origin Airport | Tampa International , Tampa, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 547 miles |
More Flight Options for Tampa (TPA) and Knoxville (TYS)
Flights from Tampa (TPA)
to Phoenix (PHX)
Flights from Tampa (TPA)
to Charlotte (CLT)
Flights from Tampa (TPA)
to Seattle (SEA)
Flights from Tampa (TPA)
to Philadelphia (PHL)
Flights from Tampa (TPA)
to Greenville (GSP)
Flights from Tampa (TPA)
to Los Angeles (LAX)
Flights from Tampa (TPA)
to Santo Domingo (SDQ)
Flights from Tampa (TPA)
to New York (LGA)
Flights from Tampa (TPA)
to San Juan (SJU)
Flights from Tampa (TPA)
to Salt Lake City (SLC)
Flights from Tampa (TPA)
to Las Vegas (LAS)
Flights from Tampa (TPA)
to Chicago (ORD)
Flights from Tampa (TPA)
to Hartford (BDL)
Flights from Tampa (TPA)
to Hartford (BDL)
Flights from Tampa (TPA)
to Boston (BOS)
Flights from Tampa (TPA)
to Islip (ISP)
Flights from Tampa (TPA)
to Mumbai (BOM)
Flights from Tampa (TPA)
to New York (JFK)
Flights from Tampa (TPA)
to Newark (EWR)
Flights from Tampa (TPA)
to Newark (EWR)
Flights from Denver (DEN)
to Knoxville (TYS)
Flights from Houston (IAH)
to Knoxville (TYS)
Flights from Boston (BOS)
to Knoxville (TYS)
Flights from San Diego (SAN)
to Knoxville (TYS)
Flights from Tampa (TPA)
to Knoxville (TYS)
Flights from Cleveland (CLE)
to Knoxville (TYS)
Flights from New York (JFK)
to Knoxville (TYS)
Flights from Houston (HOU)
to Knoxville (TYS)
Flights from Portland (PDX)
to Knoxville (TYS)
Flights from Myrtle Beach (MYR)
to Knoxville (TYS)
Flights from Nashville (BNA)
to Knoxville (TYS)
Flights from Orlando (MCO)
to Knoxville (TYS)
Flights from Chicago (MDW)
to Knoxville (TYS)
Flights from Charlotte (CLT)
to Knoxville (TYS)
Flights from New Orleans (MSY)
to Knoxville (TYS)
Flights from Omaha (OMA)
to Knoxville (TYS)
Flights from Sacramento (SMF)
to Knoxville (TYS)
Flights from Philadelphia (PHL)
to Knoxville (TYS)
Flights from Miami (MIA)
to Knoxville (TYS)
Cheap flights to North America (NA)
Cheap flights to United States (US)
Cheap flights to Florida (US-FL)
Cheap flights to Tennessee (US-TN)
Cheap flights from North America (NA)
Cheap flights from United States (US)
Cheap flights from Florida (US-FL)
Cheap flights from Tennessee (US-TN)
Flights to Tampa (TPA)
Flights to Knoxville (TYS)
Flights from Tampa (TPA)
Flights from Knoxville (TYS)
Flights from Knoxville (TYS)
to Tampa (TPA)
Why Fareleaders for TPA to TYS Plane Tickets
New Deals Everyday
Get the best prices on TPA to TYS flights—we update our fares daily so you never miss a saving.
No Service Fees
Compare hundreds of Tampa to Knoxville flights and secure the best deals—we never add any service fees.