Cheap Flight Tickets from Islip (ISP) to Knoxville (TYS), Starting at $209

Good to Know: Cheapest and Fastest ISP - TYS Flights

Useful information for finding best airline tickets from Long Island Mac Arthur to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$209

WN Southwest Airlines • 2 stops • 12h 15m

Oct 09 – Oct 12

The cheapest round trip flight from Islip to Knoxville (ISP-TYS-ISP) is currently $209

🔍 Search Flights

Fastest Flight

5h 55m

The fastest nonstop flight from Islip to Knoxville (ISP-TYS) takes 5h 55m

Top Airlines Flying from Islip to Knoxville

Southwest Airlines-WN

Southwest Airlines

Latest Flight Deals from Islip (ISP) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from Islip to Knoxville. Ideal for travelers with confirmed return itineraries.

Oct 09 - Oct 12, Economy
WN
Islip → Knoxville
12h 15m
3:10 PM - 10:45 PM • 2 stops
WN
Islip → Knoxville
15h 45m
7:15 AM - 5:00 PM • 3 stops
$209
Southwest Airlines
Oct 09 - Oct 12, Economy
WN
Islip → Knoxville
5h 55m
5:40 PM - 9:35 PM • 1 stop
WN
Islip → Knoxville
14h
8:20 AM - 5:00 PM • 1 stop
$209
Southwest Airlines
Oct 08 - Oct 12, Economy
WN
Islip → Knoxville
5h 55m
5:40 PM - 9:35 PM • 1 stop
WN
Islip → Knoxville
24h 15m
8:20 AM - 11:15 PM • 3 stops
$209
Southwest Airlines
Oct 08 - Oct 12, Economy
WN
Islip → Knoxville
19h 5m
11:00 AM - 10:45 PM • 3 stops
WN
Islip → Knoxville
10h 10m
8:20 AM - 2:30 PM • 1 stop
$209
Southwest Airlines
Oct 08 - Oct 12, Economy
WN
Islip → Knoxville
17h 15m
11:00 AM - 9:35 PM • 1 stop
WN
Islip → Knoxville
15h 45m
7:15 AM - 5:00 PM • 3 stops
$209
Southwest Airlines
Oct 09 - Oct 12, Economy
WN
Islip → Knoxville
10h 15m
6:55 AM - 1:10 PM • 1 stop
WN
Islip → Knoxville
17h 30m
12:50 PM - 11:40 PM • 2 stops
$209
Southwest Airlines

Fly from Islip to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Islip to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Islip to Knoxville Flights

What are the airports in Islip?
ISP
What’s the most popular airline flying from ISP to TYS?
The most popular airline flying from Islip to Knoxville are
Can I fly from ISP to TYS non-stop?
NO
Which airlines fly nonstop between Islip and Knoxville?
The non-stop flights between Islip and Knoxville are .
What’s the earliest departure time from ISP to TYS Airport?
The earliest flight leaves ISP at 6:55 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Islip to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from ISP to TYS?
Read the fare rules of the Islip to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Islip and Knoxville?
operate flights between Islip and Knoxville
How long does a flight from Islip to Knoxville take?
It takes approximately 2 hour to fly non-stop from ISP to TYS, which is 683.9 miles by air.
Which airlines provide the cheapest flights from Islip (ISP) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from ISP were found on WN : USD 209
Do I need a passport to fly between ISP and TYS?
No
What’s the latest departure time from ISP to TYS ?
The last flight leaves ISP at 5:40 pm

Islip (ISP) to Knoxville (TYS): Airport Information

Origin Airport Long Island Mac Arthur , Islip, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 684 miles

More Flight Options for Islip (ISP) and Knoxville (TYS)

Why Fareleaders for ISP to TYS Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Islip to Knoxville flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on ISP to TYS flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Islip to Knoxville flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Islip (ISP) to Knoxville (TYS)
Terms and Conditions*