Lowest Prices
Uncover the best deals on Des Moines to Knoxville flights by comparing fares from hundreds of airlines and agencies.
Useful information for finding best airline tickets from Des Moines International to McGhee Tyson on your next trip.
Cheapest Round Trip Flight
$276
American Airlines
• 1 stop
• 8h 32m
Nov 03 – Nov 10
The cheapest round trip flight from Des Moines to Knoxville (DSM-TYS-DSM) is currently $276
Fastest Flight
6h 46m
The fastest nonstop flight from Des Moines to Knoxville (DSM-TYS) takes 6h 46m
| Origin Airport | Des Moines International , Des Moines, US |
| Destination Airport | McGhee Tyson , Knoxville, US |
| Distance | 654 miles |