Cheap Flight Tickets from Des Moines (DSM) to Knoxville (TYS), Starting at $253

Good to Know: Cheapest and Fastest DSM - TYS Flights

Useful information for finding best airline tickets from Des Moines International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$253

UA United Airlines • 1 stop • 7h 4m

Sep 21 – Sep 28

The cheapest round trip flight from Des Moines to Knoxville (DSM-TYS-DSM) is currently $253

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Fastest Flight

7h 4m

The fastest nonstop flight from Des Moines to Knoxville (DSM-TYS) takes 7h 4m

Top Airlines Flying from Des Moines to Knoxville

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Des Moines (DSM) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from Des Moines to Knoxville. Ideal for travelers with confirmed return itineraries.

Sep 21 - Sep 28, Economy
UA
Des Moines → Knoxville
7h 4m
8:00 AM - 1:18 PM • 1 stop
AA
Des Moines → Knoxville
5h 31m
6:16 PM - 11:41 PM • 1 stop
$253
United Airlines
Sep 21 - Sep 28, Economy
UA
Des Moines → Knoxville
9h 3m
3:02 PM - 9:45 PM • 1 stop
UA
Des Moines → Knoxville
6h 46m
4:53 PM - 11:48 PM • 1 stop
$274
United Airlines
Sep 21 - Sep 28, Economy
WN
Des Moines → Knoxville
10h 20m
7:00 AM - 6:40 PM • 2 stops
WN
Des Moines → Knoxville
44h 15m
5:45 PM - 10:15 PM • 2 stops
$285
Southwest Airlines
Sep 21 - Sep 28, Economy
AA
Des Moines → Knoxville
7h 20m
7:58 PM - 10:42 PM • 1 stop
AA
Des Moines → Knoxville
4h 9m
8:15 PM - 12:04 AM • 1 stop
$355
American Airlines
Sep 21 - Sep 28, Economy
UA
Des Moines → Knoxville
7h 4m
1:23 PM - 10:49 PM • 1 stop
UA
Des Moines → Knoxville
6h 46m
4:53 PM - 11:48 PM • 1 stop
$396
United Airlines
Sep 21 - Sep 28, Economy
WN
Des Moines → Knoxville
22h
5:40 AM - 8:00 PM • 3 stops
WN
Des Moines → Knoxville
24h 10m
8:25 AM - 10:15 PM • 3 stops
$855
Southwest Airlines

Fly from Des Moines to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Des Moines to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Des Moines to Knoxville Flights

What are the airports in Des Moines?
DSM
What’s the most popular airline flying from DSM to TYS?
The most popular airline flying from Des Moines to Knoxville are
Can I fly from DSM to TYS non-stop?
NO
Which airlines fly nonstop between Des Moines and Knoxville?
The non-stop flights between Des Moines and Knoxville are .
What’s the earliest departure time from DSM to TYS Airport?
The earliest flight leaves DSM at 5:40 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Des Moines to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from DSM to TYS?
Read the fare rules of the Des Moines to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Des Moines and Knoxville?
operate flights between Des Moines and Knoxville
How long does a flight from Des Moines to Knoxville take?
It takes approximately 2 hour to fly non-stop from DSM to TYS, which is 654.44 miles by air.
Which airlines provide the cheapest flights from Des Moines (DSM) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from DSM were found on AA : USD 355
Do I need a passport to fly between DSM and TYS?
No
What’s the latest departure time from DSM to TYS ?
The last flight leaves DSM at 7:58 pm

Des Moines (DSM) to Knoxville (TYS): Airport Information

Origin Airport Des Moines International , Des Moines, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 654 miles

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