Cheap Flight Tickets from Myrtle Beach (MYR) to Knoxville (TYS), Starting at $307

Good to Know: Cheapest and Fastest MYR - TYS Flights

Useful information for finding best airline tickets from Myrtle Beach International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$307

AA American Airlines • 1 stop • 5h 14m

Sep 18 – Sep 26

The cheapest round trip flight from Myrtle Beach to Knoxville (MYR-TYS-MYR) is currently $307

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Fastest Flight

5h 8m

The fastest nonstop flight from Myrtle Beach to Knoxville (MYR-TYS) takes 5h 8m

Top Airlines Flying from Myrtle Beach to Knoxville

Delta Airline, DL

Delta Airlines

American Airlines, AA

American Airlines

Southwest Airlines-WN

Southwest Airlines

United Airlines, UA

United Airlines

Latest Flight Deals from Myrtle Beach (MYR) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from Myrtle Beach to Knoxville. Ideal for travelers with confirmed return itineraries.

Sep 18 - Sep 26, Economy
AA
Myrtle Beach → Knoxville
5h 14m
6:30 AM - 9:44 AM • 1 stop
AA
Myrtle Beach → Knoxville
5h 2m
6:06 PM - 9:08 PM • 1 stop
$307
American Airlines
Sep 18 - Sep 26, Economy
AA
Myrtle Beach → Knoxville
5h 25m
7:25 PM - 10:50 PM • 1 stop
AA
Myrtle Beach → Knoxville
5h 14m
10:12 AM - 1:26 PM • 1 stop
$307
American Airlines
Sep 18 - Sep 26, Economy
AA
Myrtle Beach → Knoxville
7h 36m
1:56 PM - 6:52 PM • 1 stop
AA
Myrtle Beach → Knoxville
5h 2m
8:18 AM - 11:20 AM • 1 stop
$307
American Airlines
Sep 18 - Sep 26, Economy
AA
Myrtle Beach → Knoxville
5h 12m
12:10 PM - 3:22 PM • 1 stop
AA
Myrtle Beach → Knoxville
5h 14m
10:12 AM - 1:26 PM • 1 stop
$307
American Airlines
Sep 18 - Sep 26, Economy
DL
Myrtle Beach → Knoxville
8h 38m
6:00 AM - 11:18 AM • 1 stop
DL
Myrtle Beach → Knoxville
5h 56m
5:45 PM - 9:41 PM • 1 stop
$681
Delta Airlines
Sep 18 - Sep 26, Economy
DL
Myrtle Beach → Knoxville
5h 8m
2:20 PM - 5:28 PM • 1 stop
DL
Myrtle Beach → Knoxville
5h 26m
11:39 AM - 3:05 PM • 1 stop
$681
Delta Airlines

Fly from Myrtle Beach to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Myrtle Beach to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Myrtle Beach to Knoxville Flights

What are the airports in Myrtle Beach?
MYR
What’s the most popular airline flying from MYR to TYS?
The most popular airline flying from Myrtle Beach to Knoxville are
Can I fly from MYR to TYS non-stop?
NO
Which airlines fly nonstop between Myrtle Beach and Knoxville?
The non-stop flights between Myrtle Beach and Knoxville are .
What’s the earliest departure time from MYR to TYS Airport?
The earliest flight leaves MYR at 6:00 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Myrtle Beach to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from MYR to TYS?
Read the fare rules of the Myrtle Beach to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Myrtle Beach and Knoxville?
operate flights between Myrtle Beach and Knoxville
How long does a flight from Myrtle Beach to Knoxville take?
It takes approximately 1 hour to fly non-stop from MYR to TYS, which is 323.45 miles by air.
Which airlines provide the cheapest flights from Myrtle Beach (MYR) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from MYR were found on AA : USD 307
Do I need a passport to fly between MYR and TYS?
No
What’s the latest departure time from MYR to TYS ?
The last flight leaves MYR at 7:25 pm

Myrtle Beach (MYR) to Knoxville (TYS): Airport Information

Origin Airport Myrtle Beach International , Myrtle Beach, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 323 miles

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