Cheap Flight Tickets from Myrtle Beach (MYR) to Knoxville (TYS), Starting at $291

Good to Know: Cheapest and Fastest MYR - TYS Flights

Useful information for finding best airline tickets from Myrtle Beach International to McGhee Tyson on your next trip.

Cheapest Round Trip Flight

$291

AA American Airlines • 1 stop • 5h 21m

Nov 04 – Nov 05

The cheapest round trip flight from Myrtle Beach to Knoxville (MYR-TYS-MYR) is currently $291

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Fastest Flight

4h 16m

The fastest nonstop flight from Myrtle Beach to Knoxville (MYR-TYS) takes 4h 16m

Top Airlines Flying from Myrtle Beach to Knoxville

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Myrtle Beach (MYR) to Knoxville (TYS)

Compare and book low fare round-trip air tickets from Myrtle Beach to Knoxville. Ideal for travelers with confirmed return itineraries.

Nov 04 - Nov 05, Economy
AA
Myrtle Beach → Knoxville
5h 21m
12:02 PM - 3:23 PM • 1 stop
AA
Myrtle Beach → Knoxville
5h 27m
8:49 AM - 12:16 PM • 1 stop
$291
American Airlines
Nov 04 - Nov 05, Economy
AA
Myrtle Beach → Knoxville
4h 16m
1:52 PM - 4:48 PM • 1 stop
AA
Myrtle Beach → Knoxville
8h 46m
6:50 AM - 12:16 PM • 1 stop
$291
American Airlines
Nov 04 - Nov 05, Economy
AA
Myrtle Beach → Knoxville
9h 5m
5:03 PM - 10:48 PM • 1 stop
AA
Myrtle Beach → Knoxville
5h 51m
8:04 PM - 11:55 PM • 1 stop
$299
American Airlines
Nov 04 - Nov 05, Economy
DL
Myrtle Beach → Knoxville
7h 25m
6:00 AM - 10:45 AM • 1 stop
DL
Myrtle Beach → Knoxville
7h 7m
5:40 AM - 10:07 AM • 1 stop
$356
Delta Airlines
Nov 02 - Nov 06, Economy
DL
Myrtle Beach → Knoxville
7h 25m
6:00 AM - 10:45 AM • 1 stop
DL
Myrtle Beach → Knoxville
8h 52m
4:11 PM - 9:43 PM • 1 stop
$356
Delta Airlines
Nov 04 - Nov 05, Economy
DL
Myrtle Beach → Knoxville
13h 42m
10:52 AM - 7:14 PM • 1 stop
DL
Myrtle Beach → Knoxville
5h 20m
6:23 PM - 9:43 PM • 1 stop
$595
Delta Airlines

Fly from Myrtle Beach to Knoxville with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Myrtle Beach to Knoxville? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Myrtle Beach to Knoxville Flights

What are the airports in Myrtle Beach?
MYR
What’s the most popular airline flying from MYR to TYS?
The most popular airline flying from Myrtle Beach to Knoxville are
Can I fly from MYR to TYS non-stop?
NO
Which airlines fly nonstop between Myrtle Beach and Knoxville?
The non-stop flights between Myrtle Beach and Knoxville are .
What’s the earliest departure time from MYR to TYS Airport?
The earliest flight leaves MYR at 6:00 am and lands in TYS - McGhee Tyson
What are the airports in Knoxville?
TYS
Can I make changes to my Myrtle Beach to Knoxville flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from MYR to TYS?
Read the fare rules of the Myrtle Beach to Knoxville air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Myrtle Beach and Knoxville?
operate flights between Myrtle Beach and Knoxville
How long does a flight from Myrtle Beach to Knoxville take?
It takes approximately 1 hour to fly non-stop from MYR to TYS, which is 323.45 miles by air.
Which airlines provide the cheapest flights from Myrtle Beach (MYR) to Knoxville (TYS) ?
In the past couple of days, the cheapest tickets to TYS from MYR were found on DL : USD 356
Do I need a passport to fly between MYR and TYS?
No
What’s the latest departure time from MYR to TYS ?
The last flight leaves MYR at 5:03 pm

Myrtle Beach (MYR) to Knoxville (TYS): Airport Information

Origin Airport Myrtle Beach International , Myrtle Beach, US
Destination Airport McGhee Tyson , Knoxville, US
Distance 323 miles

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