Lowest Prices
Uncover the best deals on Knoxville to Harrisburg flights by comparing fares from hundreds of airlines and agencies.
Useful information for finding best airline tickets from McGhee Tyson to Harrisburg International on your next trip.
Cheapest Round Trip Flight
$221
American Airlines
• 1 stop
• 5h 56m
Jun 30 – Jul 07
The cheapest round trip flight from Knoxville to Harrisburg (TYS-MDT-TYS) is currently $221
Fastest Flight
5h 56m
The fastest nonstop flight from Knoxville to Harrisburg (TYS-MDT) takes 5h 56m
| Origin Airport | McGhee Tyson , Knoxville, US |
| Destination Airport | Harrisburg International , Harrisburg, US |
| Distance | 497 miles |