Cheap Flight Tickets from Knoxville (TYS) to Buffalo (BUF), Starting at $781

Good to Know: Cheapest and Fastest TYS - BUF Flights

Useful information for finding best airline tickets from McGhee Tyson to Buffalo Niagara International on your next trip.

Cheapest One way Flight

$781

AA American Airlines • 1 stop • 35h 42m

Jul 13

The cheapest one way flight from Knoxville to Buffalo (TYS-BUF) is currently $781

🔍 Search Flights

Fastest Flight

13h 25m

The fastest nonstop flight from Knoxville to Buffalo (TYS-BUF) takes 13h 25m

Latest Flight Deals from Knoxville (TYS) to Buffalo (BUF)

Fly from Knoxville to Buffalo with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to Buffalo? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to Buffalo Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to BUF?
The most popular airline flying from Knoxville to Buffalo are
Can I fly from TYS to BUF non-stop?
NO
Which airlines fly nonstop between Knoxville and Buffalo?
The non-stop flights between Knoxville and Buffalo are .
What’s the earliest departure time from TYS to BUF Airport?
The earliest flight leaves TYS at 5:45 am and lands in BUF - Buffalo Niagara International
What are the airports in Buffalo?
BUF
Can I make changes to my Knoxville to Buffalo flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to BUF?
Read the fare rules of the Knoxville to Buffalo air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and Buffalo?
operate flights between Knoxville and Buffalo
How long does a flight from Knoxville to Buffalo take?
It takes approximately 2 hour to fly non-stop from TYS to BUF, which is 566.52 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to Buffalo (BUF) ?
In the past couple of days, the cheapest tickets to BUF from TYS were found on UA : USD 839
Do I need a passport to fly between TYS and BUF?
No
What’s the latest departure time from TYS to BUF ?
The last flight leaves TYS at 6:32 pm

Knoxville (TYS) to Buffalo (BUF): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport Buffalo Niagara International , Buffalo, US
Distance 567 miles

More Flight Options for Knoxville (TYS) and Buffalo (BUF)

Why Fareleaders for TYS to BUF Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Knoxville to Buffalo flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on TYS to BUF flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Knoxville to Buffalo flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Knoxville (TYS) to Buffalo (BUF)
Terms and Conditions*