Cheap Flight Tickets from Knoxville (TYS) to Des Moines (DSM), Starting at $448

Good to Know: Cheapest and Fastest TYS - DSM Flights

Useful information for finding best airline tickets from McGhee Tyson to Des Moines International on your next trip.

Cheapest Round Trip Flight

$448

AA American Airlines • 1 stop • 35h 35m

Aug 13 – Aug 15

The cheapest round trip flight from Knoxville to Des Moines (TYS-DSM-TYS) is currently $448

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Fastest Flight

8h 45m

The fastest nonstop flight from Knoxville to Des Moines (TYS-DSM) takes 8h 45m

Top Airlines Flying from Knoxville to Des Moines

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Knoxville (TYS) to Des Moines (DSM)

Compare and book low fare round-trip air tickets from Knoxville to Des Moines. Ideal for travelers with confirmed return itineraries.

Aug 13 - Aug 15, Economy
AA
Knoxville → Des Moines
35h 35m
1:21 PM - 9:56 AM • 1 stop
WN
Knoxville → Des Moines
12h 30m
7:20 AM - 4:10 PM • 1 stop
$448
American Airlines
Aug 13 - Aug 15, Economy
WN
Knoxville → Des Moines
25h 5m
7:10 AM - 9:15 PM • 2 stops
WN
Knoxville → Des Moines
12h 30m
7:20 AM - 4:10 PM • 1 stop
$757
Southwest Airlines
Aug 13 - Aug 15, Economy
AA
Knoxville → Des Moines
9h 5m
1:56 PM - 6:41 PM • 1 stop
AA
Knoxville → Des Moines
16h 41m
6:33 AM - 5:34 PM • 2 stops
$782
American Airlines
Aug 13 - Aug 15, Economy
WN
Knoxville → Des Moines
24h 5m
8:25 AM - 10:10 PM • 2 stops
WN
Knoxville → Des Moines
20h 50m
5:30 AM - 7:20 PM • 3 stops
$802
Southwest Airlines
Aug 13 - Aug 15, Economy
WN
Knoxville → Des Moines
39h 5m
12:40 PM - 11:25 AM • 2 stops
WN
Knoxville → Des Moines
18h 30m
5:30 AM - 5:40 PM • 3 stops
$866
Southwest Airlines
Aug 13 - Aug 15, Economy
WN
Knoxville → Des Moines
8h 45m
5:45 PM - 10:10 PM • 2 stops
WN
Knoxville → Des Moines
12h 30m
7:20 AM - 4:10 PM • 1 stop
$872
Southwest Airlines

Fly from Knoxville to Des Moines with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Knoxville to Des Moines? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Knoxville to Des Moines Flights

What are the airports in Knoxville?
TYS
What’s the most popular airline flying from TYS to DSM?
The most popular airline flying from Knoxville to Des Moines are
Can I fly from TYS to DSM non-stop?
NO
Which airlines fly nonstop between Knoxville and Des Moines?
The non-stop flights between Knoxville and Des Moines are .
What’s the earliest departure time from TYS to DSM Airport?
The earliest flight leaves TYS at 7:10 am and lands in DSM - Des Moines International
What are the airports in Des Moines?
DSM
Can I make changes to my Knoxville to Des Moines flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from TYS to DSM?
Read the fare rules of the Knoxville to Des Moines air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Knoxville and Des Moines?
operate flights between Knoxville and Des Moines
How long does a flight from Knoxville to Des Moines take?
It takes approximately 2 hour to fly non-stop from TYS to DSM, which is 654.44 miles by air.
Which airlines provide the cheapest flights from Knoxville (TYS) to Des Moines (DSM) ?
In the past couple of days, the cheapest tickets to DSM from TYS were found on AA : USD 448
Do I need a passport to fly between TYS and DSM?
No
What’s the latest departure time from TYS to DSM ?
The last flight leaves TYS at 5:45 pm

Knoxville (TYS) to Des Moines (DSM): Airport Information

Origin Airport McGhee Tyson , Knoxville, US
Destination Airport Des Moines International , Des Moines, US
Distance 654 miles

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