Lowest Prices
Uncover the best deals on Des Moines to Fort Myers flights by comparing fares from hundreds of airlines and agencies.
Useful information for finding best airline tickets from Des Moines International to Southwest Florida International on your next trip.
Cheapest Round Trip Flight
$1564
American Airlines
• 1 stop
• 10h 54m
Dec 26 – Dec 26
The cheapest round trip flight from Des Moines to Fort Myers (DSM-RSW-DSM) is currently $1564
Cheapest Direct Flight
$262
Allegiant
• nonstop
• 5h 58m
Dec 25
The cheapest nonstop flight from Des Moines to Fort Myers (DSM-RSW) is currently $262
Fastest Flight
5h 58m
The fastest nonstop flight from Des Moines to Fort Myers (DSM-RSW) takes 5h 58m
| Origin Airport | Des Moines International , Des Moines, US |
| Destination Airport | Southwest Florida International , Fort Myers, US |
| Distance | 1236 miles |