Cheap Flight Tickets from Des Moines (DSM) to San Diego (SAN), Starting at $304

Good to Know: Cheapest and Fastest DSM - SAN Flights

Useful information for finding best airline tickets from Des Moines International to San Diego International on your next trip.

Cheapest Round Trip Flight

$304

DL Delta Airlines • 2 stops • 27h 1m

Oct 29 – Nov 01

The cheapest round trip flight from Des Moines to San Diego (DSM-SAN-DSM) is currently $304

🔍 Search Flights

Fastest Flight

8h 55m

The fastest nonstop flight from Des Moines to San Diego (DSM-SAN) takes 8h 55m

Top Airlines Flying from Des Moines to San Diego

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

Latest Flight Deals from Des Moines (DSM) to San Diego (SAN)

Compare and book low fare round-trip air tickets from Des Moines to San Diego. Ideal for travelers with confirmed return itineraries.

Oct 29 - Nov 01, Economy
DL
Des Moines → San Diego
27h 1m
7:51 PM - 10:12 AM • 2 stops
DL
Des Moines → San Diego
10h
6:25 AM - 2:25 PM • 1 stop
$304
Delta Airlines
Oct 29 - Nov 01, Economy
DL
Des Moines → San Diego
23h 39m
6:55 AM - 7:14 PM • 2 stops
DL
Des Moines → San Diego
10h
6:25 AM - 2:25 PM • 1 stop
$327
Delta Airlines
Oct 29 - Nov 01, Economy
DL
Des Moines → San Diego
28h 38m
6:54 PM - 10:12 AM • 2 stops
DL
Des Moines → San Diego
27h 6m
7:59 PM - 2:25 PM • 2 stops
$358
Delta Airlines
Oct 29 - Nov 01, Economy
DL
Des Moines → San Diego
28h 24m
5:35 AM - 8:39 PM • 2 stops
DL
Des Moines → San Diego
10h
6:25 AM - 2:25 PM • 1 stop
$359
Delta Airlines
Oct 29 - Nov 01, Economy
WN
Des Moines → San Diego
8h 55m
7:10 PM - 10:45 PM • 1 stop
WN
Des Moines → San Diego
10h 40m
7:10 AM - 3:50 PM • 1 stop
$424
Southwest Airlines
Oct 29 - Nov 01, Economy
WN
Des Moines → San Diego
15h 20m
4:30 PM - 11:50 PM • 1 stop
WN
Des Moines → San Diego
7h 35m
6:15 AM - 1:10 PM • 1 stop
$472
Southwest Airlines

Fly from Des Moines to San Diego with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Des Moines to San Diego? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Des Moines to San Diego Flights

What are the airports in Des Moines?
DSM
What’s the most popular airline flying from DSM to SAN?
The most popular airline flying from Des Moines to San Diego are
Can I fly from DSM to SAN non-stop?
NO
Which airlines fly nonstop between Des Moines and San Diego?
The non-stop flights between Des Moines and San Diego are .
What’s the earliest departure time from DSM to SAN Airport?
The earliest flight leaves DSM at 5:35 am and lands in SAN - San Diego International
What are the airports in San Diego?
SAN
Can I make changes to my Des Moines to San Diego flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from DSM to SAN?
Read the fare rules of the Des Moines to San Diego air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Des Moines and San Diego?
operate flights between Des Moines and San Diego
How long does a flight from Des Moines to San Diego take?
It takes approximately 3 hour to fly non-stop from DSM to SAN, which is 1427.54 miles by air.
Which airlines provide the cheapest flights from Des Moines (DSM) to San Diego (SAN) ?
In the past couple of days, the cheapest tickets to SAN from DSM were found on DL : USD 359
Do I need a passport to fly between DSM and SAN?
No
What’s the latest departure time from DSM to SAN ?
The last flight leaves DSM at 7:51 pm

Des Moines (DSM) to San Diego (SAN): Airport Information

Origin Airport Des Moines International , Des Moines, US
Destination Airport San Diego International , San Diego, US
Distance 1428 miles

More Flight Options for Des Moines (DSM) and San Diego (SAN)

Why Fareleaders for DSM to SAN Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Des Moines to San Diego flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on DSM to SAN flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Des Moines to San Diego flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Des Moines (DSM) to San Diego (SAN)
Terms and Conditions*