Lowest Prices
Uncover the best deals on Des Moines to San Diego flights by comparing fares from hundreds of airlines and agencies.
Useful information for finding best airline tickets from Des Moines International to San Diego International on your next trip.
Cheapest Round Trip Flight
$327
Delta Airlines
• 1 stop
• 10h 39m
Dec 14 – Dec 21
The cheapest round trip flight from Des Moines to San Diego (DSM-SAN-DSM) is currently $327
Fastest Flight
10h 13m
The fastest nonstop flight from Des Moines to San Diego (DSM-SAN) takes 10h 13m
| Origin Airport | Des Moines International , Des Moines, US |
| Destination Airport | San Diego International , San Diego, US |
| Distance | 1428 miles |