Cheap Flight Tickets from Fort Myers (RSW) to Des Moines (DSM), Starting at $337

Good to Know: Cheapest and Fastest RSW - DSM Flights

Useful information for finding best airline tickets from Southwest Florida International to Des Moines International on your next trip.

Cheapest Round Trip Flight

$337

WN Southwest Airlines • 2 stops • 22h 30m

Oct 15 – Oct 17

The cheapest round trip flight from Fort Myers to Des Moines (RSW-DSM-RSW) is currently $337

🔍 Search Flights

Fastest Flight

9h 9m

The fastest nonstop flight from Fort Myers to Des Moines (RSW-DSM) takes 9h 9m

Top Airlines Flying from Fort Myers to Des Moines

Southwest Airlines-WN

Southwest Airlines

Delta Airline, DL

Delta Airlines

United Airlines, UA

United Airlines

American Airlines, AA

American Airlines

Latest Flight Deals from Fort Myers (RSW) to Des Moines (DSM)

Compare and book low fare round-trip air tickets from Fort Myers to Des Moines. Ideal for travelers with confirmed return itineraries.

Oct 15 - Oct 17, Economy
WN
Fort Myers → Des Moines
22h 30m
9:20 AM - 10:10 PM • 2 stops
WN
Fort Myers → Des Moines
16h 40m
5:50 AM - 4:50 PM • 1 stop
$337
Southwest Airlines
Oct 15 - Oct 17, Economy
WN
Fort Myers → Des Moines
39h
12:30 PM - 11:10 AM • 1 stop
WN
Fort Myers → Des Moines
21h 50m
5:50 AM - 8:00 PM • 1 stop
$342
Southwest Airlines
Oct 15 - Oct 17, Economy
WN
Fort Myers → Des Moines
13h 40m
2:50 PM - 10:10 PM • 2 stops
WN
Fort Myers → Des Moines
9h
1:20 PM - 8:00 PM • 1 stop
$345
Southwest Airlines
Oct 15 - Oct 17, Economy
WN
Fort Myers → Des Moines
13h 30m
6:10 AM - 1:20 PM • 2 stops
WN
Fort Myers → Des Moines
9h
1:20 PM - 8:00 PM • 1 stop
$345
Southwest Airlines
Oct 15 - Oct 17, Economy
DL
Fort Myers → Des Moines
12h 5m
2:35 PM - 9:00 PM • 1 stop
DL
Fort Myers → Des Moines
8h 31m
10:57 AM - 5:08 PM • 1 stop
$465
Delta Airlines
Oct 15 - Oct 17, Economy
UA
Fort Myers → Des Moines
9h 9m
4:34 PM - 9:23 PM • 1 stop
DL
Fort Myers → Des Moines
11h 54m
4:07 PM - 12:21 AM • 1 stop
$1056
United Airlines

Fly from Fort Myers to Des Moines with the Best Airfare Deals on FareLeaders

Looking for a cheap last-minute deal or the best round-trip flight from Fort Myers to Des Moines? Find the biggest savings on one-way and round-trip tickets right here.

FAQs on Fort Myers to Des Moines Flights

What are the airports in Fort Myers?
RSW
What’s the most popular airline flying from RSW to DSM?
The most popular airline flying from Fort Myers to Des Moines are
Can I fly from RSW to DSM non-stop?
NO
Which airlines fly nonstop between Fort Myers and Des Moines?
The non-stop flights between Fort Myers and Des Moines are .
What’s the earliest departure time from RSW to DSM Airport?
The earliest flight leaves RSW at 6:10 am and lands in DSM - Des Moines International
What are the airports in Des Moines?
DSM
Can I make changes to my Fort Myers to Des Moines flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from RSW to DSM?
Read the fare rules of the Fort Myers to Des Moines air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Fort Myers and Des Moines?
operate flights between Fort Myers and Des Moines
How long does a flight from Fort Myers to Des Moines take?
It takes approximately 3 hour to fly non-stop from RSW to DSM, which is 1236.38 miles by air.
Which airlines provide the cheapest flights from Fort Myers (RSW) to Des Moines (DSM) ?
In the past couple of days, the cheapest tickets to DSM from RSW were found on WN : USD 345
Do I need a passport to fly between RSW and DSM?
No
What’s the latest departure time from RSW to DSM ?
The last flight leaves RSW at 4:34 pm

Fort Myers (RSW) to Des Moines (DSM): Airport Information

Origin Airport Southwest Florida International , Fort Myers, US
Destination Airport Des Moines International , Des Moines, US
Distance 1236 miles

More Flight Options for Fort Myers (RSW) and Des Moines (DSM)

Why Fareleaders for RSW to DSM Plane Tickets

Lowest Prices
Lowest Prices
Uncover the best deals on Fort Myers to Des Moines flights by comparing fares from hundreds of airlines and agencies.
New Deals
New Deals Everyday
Get the best prices on RSW to DSM flights—we update our fares daily so you never miss a saving.
Best Travel Options
No Service Fees
Compare hundreds of Fort Myers to Des Moines flights and secure the best deals—we never add any service fees.
Get Fare Drop Alert
Be the first to know when fares drop for the Fort Myers (RSW) to Des Moines (DSM)
Terms and Conditions*