Lowest Prices
Uncover the best deals on Santa Ana to Buffalo flights by comparing fares from hundreds of airlines and agencies.
Useful information for finding best airline tickets from John Wayne -Orange County to Buffalo Niagara International on your next trip.
Cheapest Round Trip Flight
$293
Southwest Airlines
• 2 stops
• 35h 40m
Nov 03 – Nov 10
The cheapest round trip flight from Santa Ana to Buffalo (SNA-BUF-SNA) is currently $293
Cheapest One way Flight
$133
United Airlines
• 1 stop
• 10h 55m
Nov 13
The cheapest one way flight from Santa Ana to Buffalo (SNA-BUF) is currently $133
Fastest Flight
10h 55m
The fastest nonstop flight from Santa Ana to Buffalo (SNA-BUF) takes 10h 55m
| Origin Airport | John Wayne -Orange County , Santa Ana, US |
| Destination Airport | Buffalo Niagara International , Buffalo, US |
| Distance | 2199 miles |