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Uncover the best deals on Des Moines to Chicago flights by comparing fares from hundreds of airlines and agencies.
Good to Know: Cheapest and Fastest DSM - ORD Flights
Useful information for finding best airline tickets from Des Moines International to Chicago O'Hare International on your next trip.
Cheapest Round Trip Flight
$416
American Airlines
• nonstop
• 2h 22m
Jun 24 – Jun 25
The cheapest round trip flight from Des Moines to Chicago (DSM-ORD-DSM) is currently $416
Cheapest Direct Flight
$416
American Airlines
• nonstop
• 2h 22m
Jun 24
The cheapest nonstop flight from Des Moines to Chicago (DSM-ORD) is currently $416
Fastest Flight
2h 15m
The fastest nonstop flight from Des Moines to Chicago (DSM-ORD) takes 2h 15m
Top Airlines Flying from Des Moines to Chicago
Latest Flight Deals from Des Moines (DSM) to Chicago (ORD)
Compare and book low fare round-trip air tickets from Des Moines to Chicago. Ideal for travelers with confirmed return itineraries.
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 22m
5:00 AM - 6:42 AM • nonstop
Des Moines → Chicago
2h 15m
6:00 PM - 7:35 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 37m
7:09 PM - 9:06 PM • nonstop
Des Moines → Chicago
2h 19m
5:00 PM - 6:39 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 22m
5:00 AM - 6:42 AM • nonstop
Des Moines → Chicago
8h 58m
6:20 PM - 11:58 PM • 1 stop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 21m
8:05 PM - 9:46 PM • nonstop
Des Moines → Chicago
8h 33m
10:50 AM - 4:03 PM • 1 stop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
8h 45m
6:55 AM - 12:20 PM • 1 stop
Des Moines → Chicago
2h 15m
6:00 PM - 7:35 PM • nonstop
American Airlines
Flying to Chicago soon? We've surfaced some of the most affordable last-minute flights from Des Moines to Chicago, ideal for urgent plans or spontaneous trips.
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 22m
5:00 AM - 6:42 AM • nonstop
Des Moines → Chicago
2h 15m
6:00 PM - 7:35 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 37m
7:09 PM - 9:06 PM • nonstop
Des Moines → Chicago
2h 19m
5:00 PM - 6:39 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 22m
5:00 AM - 6:42 AM • nonstop
Des Moines → Chicago
8h 58m
6:20 PM - 11:58 PM • 1 stop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 21m
8:05 PM - 9:46 PM • nonstop
Des Moines → Chicago
8h 33m
10:50 AM - 4:03 PM • 1 stop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
8h 45m
6:55 AM - 12:20 PM • 1 stop
Des Moines → Chicago
2h 15m
6:00 PM - 7:35 PM • nonstop
American Airlines
Looking for the fastest way to Chicago? These direct flight options from DSM to ORD offer both convenience and value—no layovers, just straight to your destination.
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 22m
5:00 AM - 6:42 AM • nonstop
Des Moines → Chicago
2h 15m
6:00 PM - 7:35 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 37m
7:09 PM - 9:06 PM • nonstop
Des Moines → Chicago
2h 19m
5:00 PM - 6:39 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 22m
9:23 AM - 11:05 AM • nonstop
Des Moines → Chicago
2h 19m
5:00 PM - 6:39 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 21m
8:05 PM - 9:46 PM • nonstop
Des Moines → Chicago
2h 19m
5:00 PM - 6:39 PM • nonstop
American Airlines
Jun 24 - Jun 25, Economy
Des Moines → Chicago
2h 22m
1:51 PM - 3:33 PM • nonstop
Des Moines → Chicago
2h 15m
11:00 PM - 12:35 AM • nonstop
American Airlines
FAQs on Des Moines to Chicago Flights
What are the airports in Des Moines?
DSM
What’s the most popular airline flying from DSM to ORD?
The most popular airline flying from Des Moines to Chicago are
Can I fly from DSM to ORD non-stop?
Yes, you can fly DSM to ORD non-stop on
Which airlines fly nonstop between Des Moines and Chicago?
The non-stop flights between Des Moines and Chicago are .
What’s the earliest departure time from DSM to ORD Airport?
The earliest flight leaves DSM at 5:00 am and lands in ORD - Chicago O'Hare International
What are the airports in Chicago?
MDW,ORD
Can I make changes to my Des Moines to Chicago flight tickets or cancel them on FareLeaders.com?
No. We are an airfare comparison site. All the tickets are booked by the travel agent offering the flight deal and any changes or cancellations to be made are directly done directly by them or the airlines.
Can I cancel my flight tickets from DSM to ORD?
Read the fare rules of the Des Moines to Chicago air tickets booked. Some airlines allow you to cancel the tickets within a stipulated time period with a cancellation fee.
Which airline alliances offer flights from Des Moines and Chicago?
operate flights between Des Moines and Chicago
How long does a flight from Des Moines to Chicago take?
It takes approximately 1 hour to fly non-stop from DSM to ORD, which is 299.09 miles by air.
Which airlines provide the cheapest flights from Des Moines (DSM) to Chicago (ORD) ?
In the past couple of days, the cheapest tickets to ORD from DSM were found on AA : USD 421
Do I need a passport to fly between DSM and ORD?
No
What’s the latest departure time from DSM to ORD ?
The last flight leaves DSM at 8:05 pm
Des Moines (DSM) to Chicago (ORD): Airport Information
| Origin Airport | Des Moines International , Des Moines, US |
| Destination Airport | Chicago O'Hare International , Chicago, US |
| Distance | 299 miles |
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